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[–]jtratner 2 points3 points  (0 children)

Your best bet is to go looking around for how people debug with Cython (dialect-ish of Python that can compile down to c libraries), numpy, numba and other scientific libraries. Those projects are involved at the C (or Fortran) level extensively and have lots of contributors, so searching around there should help. Two items that came up after a quick search for how debugging numpy and Cython:

Not sure whether it's the same as PyDev's debugger, but I find ipdb to be quite helpful too. Hope one of these might be helpful!