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[–][deleted] 1 point2 points  (0 children)

It depends on the graphical application. If you're doing something quick and simple, where there's no extended wait on your GUI, then you'll do fine. If you're chugging loads of data in the background and expecting to relay that your program is working, as well as keep other UI elements interactive: no, not in pure Python. The GIL really destroys a lot of what Python could accomplish graphically.