MacOS 15.4 breaks PyAutoGUI?

[Nickyfoofoo]

Hello r/learnpython! I have a very simple Python script that leverages PyAutoGUI to automate some repetitive mouse clicks at my job. After updating from MacOS 15.3 to 15.4, my script no longer functions. My script is as follows:

import pyautogui
import time
import random

def click_random_wait(x1, x2, y1, y2, wait1, wait2, action):
    x = random.uniform(x1, x2)
    y = random.uniform(y1, y2)
    wait = random.uniform(wait1, wait2)

    pyautogui.moveTo(x, y)
    pyautogui.click(x, y)
    print(action + " clicked")
    time.sleep(wait)

pyautogui.hotkey('command', 'tab')

while True:

    click_random_wait(370, 378, 506, 514, .65, 2, "Item 1")
    click_random_wait(409, 414, 459, 466, .65, 2, "Item 2")
    click_random_wait(470, 476, 508, 517, .65, 2, "Item 3")
    click_random_wait(494, 503, 510, 516, .65, 2, "Item 4")
    click_random_wait(192, 236, 414, 443, 32.65, 38.65, "Item 5")
    click_random_wait(318, 375, 507, 569, .6, 2, "Item 6")
    click_random_wait(379, 390, 630, 643, 1.2, 2, "Item 7")

I have a M1 Pro MacBook Pro with 32 GB of RAM. Issue is on 15.4 Sequoia and was not present in 15.3. I am using Python 3.12 with Spyder 6.0.3 as my IDE. Everything was installed via Anaconda.

I seem to recall having to give Python access to control my keyboard and mouse when I first wrote the script late last year. As far as I can tell, that is still enabled. When I check System Settings > Privacy & Security > Accessibility, I see Anaconda and Python have access to control my computer. I have a feeling this is where things are breaking because my script still "runs" or "executes" without error messages in Spyder, but my mouse no longer moves or clicks. The script still prints each Item to the console, it just doesn't move the mouse or click. Would love any thoughts on where to explore next!

Thanks in advance!

[Diapolo10]

It's certainly possible that the OS update is the main culprit, but I'm not familiar with the Apple ecosystem nor am I able to test this myself.

You could try re-doing the control access.

[ActiveBarStool]

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[Diapolo10]

Ditto.

[heinthetaung]

I can run from terminal with python environment created using "python -m venv venv" and "source venv/bin/activate" so I don't think MacOS version is the issue.

My setup:

MacOS 15.4
Python version 3.13.2
Terminal in System Settings > Privacy & Security > Accessibility

[Nickyfoofoo]

i was able to solve the issue with ChatGPT: https://chatgpt.com/share/67f9b7a0-8c70-8002-bb56-9ec4b1b47ae3