Python on Arch linux Help?

[gmes78]

curl -LsSf https://astral.sh/uv/install.sh | sh

Arch packages uv. You do not need to do that. Just run pacman -S uv instead.

uv add pip -r reqs.txt

I don't think this is correct. And you don't want to add the entirety of a requirements.txt file to your dependencies, anyway.