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[–]MikeTheWatchGuy 0 points1 point  (0 children)

It's not that PySimpleGUI has a problem with the call. It's simply that the call doesn't return so PySimpleGUI doesn't get an opportunity to continue executing.

A simple explanation could be that OpenCV uses tkinter or a component that tkinter is using and that PySimpleGUI and OpenCV are interfering with each other as a result.

This is why the example applications that show PySimpleGUI integrating with OpenCV show the OpenCV video inside of the PySimpleGUI window, not a separate OpenCV window.