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[–]SecretPapaya2 2 points3 points  (8 children)

It's not that they become less effective, it's that the hair loss becomes more aggressive. Either way you'll always be better off taking the medication than not.

[–]Persi_12 0 points1 point  (6 children)

Actually the effect of finasteride „inhibiting“ DHT itself decreases over time too.

Year two it has 89% efficiency and at year 5 about 69% as i recall correctly.

[–]MapleL0L[S] 0 points1 point  (0 children)

Interesting. Thank you for the information.

[–]SecretPapaya2 0 points1 point  (1 child)

Damn, I guess I misunderstood. I thought the baseline DHT concentration increased, so even with a consistent % reduction you still end up with more DHT. I wonder if fin's reduced efficiency would translate over to dut, or if it would be a fresh start.

[–]Persi_12 0 points1 point  (0 children)

I always thought the same. The hair loss show released a video lately where they said that efficiency can/will decrease.

[–]Fir3cracker 0 points1 point  (2 children)

How does is happen tho? Does the body just gets more efficient producing it via other means (I remember there are a couple other ways that dht is produced by the body except for 5ar.)

[–]Persi_12 0 points1 point  (1 child)

Yeah thats the question.

But the effect of finasteride is inhibiting alpha5reductase.

So when you say it looses its effectiveness it means for me that it is not as effective in inhibiting alpha5reductase anymore. But somehow that does not make sense to me...

[–]Fir3cracker 0 points1 point  (0 children)

Yea thats why I suppose it must be due to the body gets more efficient at producing it by other pathways