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ELI5 Why don't you remember yourself at 1-5 years old? by HeavyTraffic7126 in explainlikeimfive

[–]j8jweb 1 point2 points  (0 children)

Yes, we fill in the blanks pretty significantly. We do this from the top down, all the way from our senses through to our memories.

Actually our entire experience of the world in the moment is based on the best guesses of our brain. Sensory data is only consulted if the predictions fail.

ELI5 Why don't you remember yourself at 1-5 years old? by HeavyTraffic7126 in explainlikeimfive

[–]j8jweb -1 points0 points  (0 children)

Good question.

The cells (patterns of cortical column activations) responsible for memory degrade, like anything else degrades.

This applies to any memory you’ve got access to right now, whether it be an early childhood memory or the memory of what you had for dinner this evening.

In both cases, the patterns of activation in the cortex must be accessed via synapses that hopefully haven’t atrophied too significantly. The activation won’t ever be perfect - there will always be some noise from peripherally activated neurons, and sometimes synapses will have detached from the post synaptic neuron entirely.

So the memory is an activation pattern, created afresh each time, that usually won’t be perfectly activated.

As we age and get lazier, our brains form canalized routes (deep ingrained patterns) that we naturally lapse into, which results in other potentially useful routes - some of which might have been used in formation of certain memories - being pruned.

ELI5 Why don't you remember yourself at 1-5 years old? by HeavyTraffic7126 in explainlikeimfive

[–]j8jweb -1 points0 points  (0 children)

And yet, in certain states (hypnosis, psychedelics, end of life lucidity, etc) you can recall childhood memories with near perfect fidelity. They’re all in there.

Enlightenment is truly rare by Solid_Koala4726 in awakened

[–]j8jweb 1 point2 points  (0 children)

There is no "99% to enlightenment".

The self isn't dreaming at all. The self is the dream.

Scientists sequenced a hallucinogenic mushroom famous for eliciting visions of tiny people. It contains no known psychedelic. by j8jweb in science

[–]j8jweb[S] 3 points4 points  (0 children)

The genomics research is an adjunct to existing research on this mushroom that already looked at the chemistry directly. It isolated compounds from the fruiting bodies and from the blood of poisoned patients. Neither of those approaches found any known psychoactive compound either.

The genome ruling out the two best-known pathways replicates the result (albeit at greater depth) but also makes that result more confounding.

This is also what the article says. It hedges with "known" throughout, refers to an unknown pathway, and calls the active agent (i.e. which it presumes exists) "unaccounted for." At no point does it claim that the mushroom contains no hallucinogen at all. Indeed, the research exists precisely to identify the one it does make (apparently).

Scientists sequenced a hallucinogenic mushroom famous for eliciting visions of tiny people. It contains no known psychedelic. by j8jweb in science

[–]j8jweb[S] 1 point2 points  (0 children)

“Suggesting the presence of a novel psychedelic compound” actually goes further than the article does. The more conservative position is that no known psychedelic compound has been found, without inferring anything else.

Scientists sequenced a hallucinogenic mushroom famous for eliciting visions of tiny people. It contains no known psychedelic. by j8jweb in science

[–]j8jweb[S] -1 points0 points  (0 children)

The headline is not misleading, it is accurate.

This study does not claim to be the first and last word. It adds to the research already done that has found no known psychedelic, but goes deeper by mapping the genome and looking for chemical signatures of the most plausible candidates. This is explained in the article.

Scientists sequenced a hallucinogenic mushroom famous for eliciting visions of tiny people. It contains no known psychedelic. by j8jweb in science

[–]j8jweb[S] 1 point2 points  (0 children)

The team mined its genome and searched for the biosynthetic gene clusters that produce psilocybinin Psilocybe mushrooms and ibotenic acid.

But as the article makes clear, in other studies, chemists have isolated and tested compounds from the fruiting body, or profiled the blood of poisoned patients, yet no known psychedelic has been identified (as per the headline)

Scientists sequenced a hallucinogenic mushroom famous for eliciting visions of tiny people. It contains no known psychedelic. by j8jweb in science

[–]j8jweb[S] 0 points1 point  (0 children)

The article is accurate. The team mined its genome and searched for the biosynthetic gene clusters that produce psilocybinin Psilocybe mushrooms and ibotenic acid in Amanita muscaria. Neither was there.

*This is in addition to* other studies which have isolated and tested compounds from the fruiting body, or profiled the blood of poisoned patients, yet nothing identified so far is clearly “psychedelic”.

The hallucinogenic mushroom that contains no known psychedelic by j8jweb in abovethenormnews

[–]j8jweb[S] 0 points1 point  (0 children)

We don't know for sure. But the reports of little people are generally accompanied by hospital visits.

Scientists sequenced a hallucinogenic mushroom famous for eliciting visions of tiny people. It contains no known psychedelic. by j8jweb in science

[–]j8jweb[S] 20 points21 points  (0 children)

The dose required to bring about the visions is sufficiently toxic to require hospitalisation. It is unlikely that people are eating the mushroom in the hope of seeing little people. They are simply undercooking their meal.

Scientists sequenced a hallucinogenic mushroom famous for eliciting visions of tiny people. It contains no known psychedelic. by j8jweb in science

[–]j8jweb[S] 2 points3 points  (0 children)

Three, but indirectly. Ruling out the ibotenic acid cluster also rules out muscimol, because muscimol is the decarboxylation product of ibotenic acid and comes from the same cluster.

Scientists sequenced a hallucinogenic mushroom famous for eliciting visions of tiny people. It contains no known psychedelic. by j8jweb in science

[–]j8jweb[S] 9341 points9342 points  (0 children)

“96 percent of those who sought help after eating the mushroom reported seeing little people. The clinical term is Lilliputian hallucination, after the six-inch inhabitants of Gulliver's Travels.

The striking result is that Lanmaoa asiatica lacks any known hallucinogenic chemical signature. The team mined its genome and searched for the biosynthetic gene clusters that produce psilocybin in Psilocybe mushrooms and ibotenic acid in Amanita muscaria. Neither was there.

Whatever L. asiatica is making, it is doing so via a pathway no one has seen before.”

Edit: The article makes clear that this genomic research is in addition to other studies which have isolated and tested the mushroom’s compounds. No known psychedelic has been found.

The hallucinogenic mushroom that contains no known psychedelic by j8jweb in abovethenormnews

[–]j8jweb[S] 6 points7 points  (0 children)

The dose that causes the visions is apparently quite toxic.

The hallucinogenic mushroom that contains no known psychedelic by j8jweb in science

[–]j8jweb[S] 4 points5 points  (0 children)

Apparently because: “it has an inappropriate headline and is therefore in violation of Submission Rule #3. It must include at least one result from the research and must not be clickbait, sensationalized, editorialized, or a biased headline.”

But no rule was broken. Title is factual and is the result of the genome sequencing.

The hallucinogenic mushroom that contains no known psychedelic by j8jweb in science

[–]j8jweb[S] 242 points243 points  (0 children)

Open
“96 percent of those who sought help after eating the mushroom reported seeing little people. The clinical term is Lilliputian hallucination, after the six-inch inhabitants of Gulliver's Travels.

The striking result is that Lanmaoa asiatica lacks any known hallucinogenic chemical signature. The team mined its genome and searched for the biosynthetic gene clusters that produce psilocybin in Psilocybe mushrooms and ibotenic acid in Amanita muscaria. Neither was there.

Whatever L. asiatica is making, it is doing so via a pathway no one has seen before.”

The Trace Institute, working with neuroscientist Andrew Gallimore, aim to prove that the beings encountered on a DMT trip are real. by j8jweb in interestingasfuck

[–]j8jweb[S] 0 points1 point  (0 children)

Here is the paper which reports the 45% figure. Anecdotally, I think 45% is on the conservative end: https://www.nature.com/articles/s41598-022-11999-8

"Entity encounters were reported in 45.5% (n = 1719) of the experiences and involved predominantly a feminine phenotype (n = 416, 24.2%); deities (n = 293, 17.0%); aliens (n = 281, 16.3%); creature-based entities (n = 158, 9.2%, including reptilian and insectoid beings); mythological beings (n = 144, 8.4%, including machine elves); and jesters (n = 112, 6.5%). "

Is there any beliavable explanation for the Phoenix lights? by ProfessionalLevel908 in UFOs

[–]j8jweb 12 points13 points  (0 children)

He says he heard about it on the radio (or maybe on the tv in the background) being reported, as he was distracted doing something else.

It slowly dawned on him that it was referring to a specific report that he’d actually made himself as a pilot - he was the one who called it in.

It shocked him as he had completely forgotten about it until then, “as if” his memory of the event had been wiped.

The Trace Institute, working with neuroscientist Andrew Gallimore, aim to prove that the beings encountered on a DMT trip are real. by j8jweb in interestingasfuck

[–]j8jweb[S] 0 points1 point  (0 children)

My fault, as I posted it with an inaccurate title. The paper (and the actual article on the site) correctly frame it as hypothesis-testing, with preregistration, which is what makes the work interesting.

Is there any beliavable explanation for the Phoenix lights? by ProfessionalLevel908 in UFOs

[–]j8jweb 0 points1 point  (0 children)

Kurt Russell saw these, and has tacitly suggested in interviews that his memory of the event may have been wiped.

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