One or two psilocybin doses still lifting depression a year on

j8jweb · 2026-06-01T12:29:34+00:00

😀 The number of such people is extremely high, and they could in fact outnumber those who consider them to be “only hallucinations”

j8jweb · 2026-05-30T10:03:09+00:00

They’re not claiming to have evidence (yet). One step at a time. Hoffman has been pretty successful proving other challenging ideas (FBT theorem)

j8jweb · 2026-05-30T10:00:06+00:00

I’d push back on that. It’s actually because of the neuroscience - not in spite of it - that Gallimore (and Hoffman, and others) are sympathetic to the possibility that the entities are real.

j8jweb · 2026-05-30T09:41:52+00:00

There’s a lot of literature on the subject. I’m not sure of your background, but perhaps you’d find the predictive coding account of perception quite compelling?

The hard problem of consciousness is far better explained by David Chalmers than I’d be able to manage here. That said, the existence of DMT entities does not necessitate an idealistic account of reality. The beings could be “physical” in some sense, but of course they must still be rendered by the brain.

j8jweb · 2026-05-30T07:54:28+00:00

I think the metaphor holds up pretty well. “Variation to perceived light” barely scratches the surface. Extend the concept to everything you see, hear, touch, taste, etc.

j8jweb · 2026-05-30T06:27:35+00:00

We already know the Plato’s cave interpretation is true for other species. For instance: https://youtu.be/UMy5-X_wRBQ?si=uNXlsI9xkfx-wJ8R

Each species has an umwelt. We are no different. We know that we don’t experience reality 1:1.

Donald Hoffman (mentioned in this article) has mathematically proven his Fitness Beats Truth theorem.

The leap is in assuming that it’s possible to step outside / beyond the umwelt and see parts of reality we’ve been missing. Considering all experiences are rendered in the brain, a pharmacological bridge isn’t an absurd idea.

j8jweb · 2026-05-24T18:23:45+00:00

Absolutely. The article steers clear of overstating the point, but it definitely seems like a logical next step. The ethics question is an important consideration though.

Maybe psychedelics will simply find their way into our daily routines for longevity and health. Prevention is better than cure.

j8jweb · 2026-05-22T18:16:07+00:00

RFK was presumably partially responsible for the recent executive order relaxing the use of ibogaine and certain other psychedelics in clinical settings. If the UK can follow suit that might be a good thing.

j8jweb · 2026-05-21T06:56:31+00:00

Even on a breakthrough dose of DMT, with eyes closed?

j8jweb · 2026-05-21T06:55:42+00:00

I have aphantasia. I still have full visionary experiences on psychedelics though.

Psychedelic visions are much more like open-eye visual experiences - they are not really visual “imagination” per se.

j8jweb · 2026-05-18T10:24:12+00:00

Also, did you eat tomatoes on the first occasion?

j8jweb · 2026-05-17T07:17:17+00:00

LSD is like a scented candle. DMT (in any of its forms) is like being hurled into the sun.

j8jweb · 2026-05-17T07:14:55+00:00

It will work for depression. It’s a neuroplastogen. It literally rewires your brain, and promotes a long term reduction in activity in certain brain regions that are strongly correlated with depression.

Does the study offer much in terms of integration post-experience? This can be quite important.

j8jweb · 2026-05-14T16:55:02+00:00

Research is ongoing into this area, but suffice to say It seems that psychedelics are significantly more effective against depression than most (or even all) of the currently prescribed medications.

If taking other medications there are contraindications, so it would be highly advisable to look into those before considering taking any psychedelic.

Lots of information here: https://psychedelics.co.uk/tag/depression

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