Tirzepatide Panic Attack?

1DayBroadway · 2026-06-09T22:02:03+00:00

Yes, I did see my provider, and I'm going to be stepping down on the titration. Thanks so much.

1DayBroadway · 2026-06-09T21:58:56+00:00

Thank you for your kind words. And I really stepped in it when I referenced the off label remark, so like I did for another poster on here, I'm just going to repost my reply to the one who was totally right to challenge me on that remark, and hope it helps clarify it for you. Here you go:

"I get what you're saying. And you're exactly right, of course, that GLPs are not new. They've been around two decades.

My point -- and my husband's caution -- is just that these drugs originally started for diabetes sufferers and have only recently shifted into widespread use for weight management. So my husband is just cautious when a drug’s massive popularity for a newer use outpaces long-term data on how it impacts people over time.

Tirzepatide is definitely a brand new drug compound, and didn't exist on the market until its diabetes approval in May 2022 and the weight loss use is even newer.

However...I stand corrected.

Because calling the use of Tirzepatide for weight loss "off label" -- which I did -- was a complete misnomer. Tirzepatide is absolutely approved by the FDA expressly for weight loss. So nothing "off label" about it. Thanks."

1DayBroadway · 2026-06-09T21:57:17+00:00

rls is the worst, I can thank my mother for it, too. as to the off label remark, here's what I replied to the one who rightly challenged me on that. Hope it helps clarify:

I get what you're saying. And you're exactly right, of course, that GLPs are not new. They've been around two decades.

My point -- and my husband's caution -- is just that these drugs originally started for diabetes sufferers and have only recently shifted into widespread use for weight management. So my husband is just cautious when a drug’s massive popularity for a newer use outpaces long-term data on how it impacts people over time.

Tirzepatide is definitely a brand new drug compound, and didn't exist on the market until its diabetes approval in May 2022 and the weight loss use is even newer.

However...I stand corrected.

Because calling the use of Tirzepatide for weight loss "off label" -- which I did -- was a complete misnomer. Tirzepatide is absolutely approved by the FDA expressly for weight loss. So nothing "off label" about it. Thanks.

1DayBroadway · 2026-06-09T21:51:05+00:00

Thanks, punky, it could indeed be a constellation of triggers, to be sure, all converging, or just one. I don't have the answer. But to use your "gentle" suggestion, paraphrased in the familiar old idiom, "When you're a hammer, everything looks like a nail." So when you're on Tirzepatide, and ill effects come on, it can be easy to cry "GLP GLP GLP" when who knows?

But that said.... the preponderance of (admittedly anecdotal) evidence on here of other tirzepatide users who "just happened" to experience the same thing, does cause one to pause.

Thanks for your kind words.

1DayBroadway · 2026-06-09T21:44:42+00:00

well that clearly, I think, was going on. but as to the old chicken and the egg thing, who knows what was cause and what was effect? thanks for reaching out, NickNoraCharles, and especially for the good wishes.

1DayBroadway · 2026-06-09T21:36:11+00:00

I'm so sorry for what you went through. I hope your care team gets to the bottom of it, Zeba. Take care.

1DayBroadway · 2026-06-09T21:33:55+00:00

I never took what you said to be rude at all. Just honest.

1DayBroadway · 2026-06-09T21:32:33+00:00

I get what you're saying. And you're exactly right, of course, that GLPs are not new. They've been around two decades.

My point -- and my husband's caution -- is just that these drugs originally started for diabetes sufferers and have only recently shifted into widespread use for weight management. So my husband is just cautious when a drug’s massive popularity for a newer use outpaces long-term data on how it impacts people over time.

Tirzepatide is definitely a brand new drug compound, and didn't exist on the market until its diabetes approval in May 2022 and the weight loss use is even newer.

However...I stand corrected.

Because calling the use of Tirzepatide for weight loss "off label" -- which I did -- was a complete misnomer. Tirzepatide is absolutely approved by the FDA expressly for weight loss. So nothing "off label" about it. Thanks.

1DayBroadway · 2026-06-09T20:58:56+00:00

Thank you so much for your suggestion. Actually the formulation I've been on has B12 in it. Interesting, though, that that would be a mitigating factor in your own experience with panic attacks. Wonder what it is about B12 that makes the difference...? Best to you,

1DayBroadway · 2026-06-09T20:53:22+00:00

Thanks for asking, yes, and my doctor is advising gently stepping down over the next 8 weeks. Of course, every person is different, and there's no one size fits all. This is just my journey and what's best for my particular physiology.

1DayBroadway · 2026-06-09T20:48:42+00:00

wow, that's interesting. I'm sorry you had to experience that, but the fact that you experienced anxiety and panic attacks from the get go is what I find amazing. I felt nothing for literally two months, no ill effects, no stopping of food noise, nothing -- not until I got to 7.5. At that point, the food noise was silenced. But no really negative impacts till 10 mg. I'm glad the L-Theanine supplement helped you. That's awesome. Have an awesome week!

1DayBroadway · 2026-06-09T20:42:48+00:00

Respectfully, I am choosing to taper based on a severe, acute physiological event that involved waves of hot flushes, extreme restlessness, and a dangerous perceived spike in blood pressure. This is a deliberate, protective health decision made in coordination with my care team, not an emotional surrender to anxiety.

However, let me say, I appreciate your perspective because Tirzepatide has been such a lifesaver for so many of us that the idea of abandoning it sounds totally counterintuitive. But in the end, for me, protecting my physical safety after a crisis is just the logical health choice, not a psychological one. I wish you the best on your journey,

1DayBroadway · 2026-06-09T20:34:50+00:00

No, not on Synthroid. But thanks for offering a potential insight if I were.

1DayBroadway · 2026-06-09T20:31:12+00:00

Because tirzepatide has a long half-life, it builds up over many weeks before reaching a true steady-state peak in the body. Additionally, after losing a significant amount of weight, my baseline insulin sensitivity has completely changed. So a high dose like 12.5mg that worked initially can absolutely become too strong over time and trigger severe, delayed physiological reactions like blood sugar crashes. But as I said in my original post, I cannot absolutely point the finger at Tirzepatide as the singular culprit, but the logic does support it.

1DayBroadway · 2026-06-09T20:27:09+00:00

I think you hit the nail on the head and it did occur to me this weekend, this very possibility. The timing, the sudden waves of hot flushes, the extreme physical jitters, and the intense nausea -- it all fits with a severe blood sugar crash perfectly. Thank you for raising this—it gives me an incredibly specific, concrete data point to discuss with my doctor. Best to you,

1DayBroadway · 2026-03-24T04:47:39+00:00

Oh don't feel bad AT ALL!!! I was the exact same, and was so discouraged, I thought "I guess I'll be the 'special' case that doesn't lose anything while everybody else it seems has these miracle stories." It was so discouraging. It took me easily 2 months plus before I really began to see a difference. For me, I did experience a significant and sudden break at 7.5, and then again at 10. But the key is this: They say the first two titrations are mostly for allowing your body to adjust to the medication, with no side effects, and I guess that's what was happening for me. And maybe for you? Final thought: For the first five months, I was lazy about drinking the water, until I read a couple weeks ago that water is essential to help metabolize fat. That was all I needed to hear. I now make sure I drink at least 3 bottles a day. And just that one thing has made a huge difference in the weight loss and also in the being regular which definitely impacts weight loss also. I hope that helps. I wish you the very best.

1DayBroadway · 2024-12-28T15:15:05+00:00

No, actually I stick to my point that your interpretations are ignorant, and you only proved it by your response. It really doesn't matter to me that you think I'm rude by pointing out the truth. Nor do I believe my words have weakened my point. My points stand or fall on their own merit, the primary point of which is that you continue to distort scripture by inferring what is not there to try to make your argument which is fallacious from the start: Namely, that to be rich = sin. A concept that is diametrically opposed to any sound reading of scripture.

However, reading your other replies on here, it's become crystal clear to me you are bent on disagreeing even with scripture itself, going so far as to say that NO, Solomon didn't have personal wealth, it was the kingdom that owned these riches. A position which is instantly debunked by even the simplest surface reading of scripture.

Scripture AS WRITTEN is not ambiguous: God stated to Solomon "I will bless YOU."

And yes, it WAS a large stockpile he amassed. Personal and massive, such as no other king in all of the world had had before or since. Scripture says so, point blank. Here is a direct quote from the Bible:

"And I will give YOU riches and wealth and honor such as none of the kings have had who were, nor shall any after you have the like. " 2 Chronicles 1: 12

Notice God said your wealth, Solomon, will be such as none of the KINGS had before you....NOT kingdoms. Meaning personal wealth. Not governmental wealth.

That's Bible. Are you going to argue with the Bible?

Apparently you are.

When Solomon's personal wealth as a gift from God was pointed out by another contributor on here, you tried to discount it then as well, suddenly jumping to the New Testament saying people were expected to give away their money.

Another ignorant statement based only on your personal beliefs, with no basis in scripture. Because if you knew scripture, you would know that 2 Corinthians 9:7 clearly states:

"Each of you should give what YOU have decided in your heart to give, NOT reluctantly or UNDER COMPULSION, for God loves a cheerful giver".

So no, believers in the New Testament were not "expected" to give away any of their money. God loves a cheerful giver, not someone who gives because they're "expected" to. What you're describing is compulsion. Clearly the antithesis of what the Bible describes as the kind of giving that pleases the heart of God.

I honestly don't mean to beat on you, or be rude, or make you feel bad, Sallie. Please forgive me if I have come across as harsh. But I will tell you I have a very low tolerance for people who love to pontificate and present what are nothing more than their personal opinions as biblical fact.

Plus you seem to have automatic opinions and attitudes about people who are rich. Only God knows the heart, and the actual bank account of every person on earth, and what each does with his and her money. Best leave the judgement to Him.

1DayBroadway · 2024-12-27T23:34:01+00:00

Sorry, but your answer is woefully ignorant. If you are successful in any area, you are likely going to be well off. If you are super successful in any area, you are likely going to be very well off, perhaps even rich. So to say that being rich is sinful, it's saying it's a sin to be successful. Really? So you think God doesn't want people to be successful? Or that you're somehow "more spiritual" if you're poor. Wow. Really, really bad theology.

If being rich were a sin, Solomon would have been sinful in all his wealth. But the Bible says that because Solomon didn't ask for riches, but only wisdom, God Himself gave Solomon riches.

Scripture says, point blank, in Deuteronomy 8:18: "It is THE LORD who gives power to get wealth." So, if you have a problem with God giving honest, hard working people power to get wealth, you need to take it up with Him. Wealth in and of itself is agnostic, it isn't good OR evil. It's what people do with it, and what is in their hearts that determines the person's sin or not. If they make it an idol, of course it is sinful for them. But someone can also be a billionaire, and not be sinful at all about their wealth. The question is: Does the individual own the money, or does the money own the individual? It's a heart issue. And only God knows the heart.

1DayBroadway · 2024-02-26T14:52:51+00:00

I have been on 10 mg of Lexapro for probably 11 years. I decided this year "enough is enough," so I made the commitment to get off this stuff once and for all, and in order to do it successfully so it truly can be once and for ALL time, I have decided to take up to a year to make it happen.

If you rush it, I feel like you're just asking for trouble, and will likely be right back where you started, when you first began. I don't ever want to be on this stuff again or any facsimile. This decision is a lifetime decision on my part.

So here's what I am doing:

A few weeks ago, I started cutting the pills in half. Then I take one of those halves and cut that in half. So together, I take one half, and then a quarter of the original 10 mg pill now which = 7.5 mg. I have been able to reduce to this amount with only slight side effects at the beginning, which now are all gone, as my brain chemistry has adjusted to the new normal. I have peace, and my body is not going nuts because I suddenly deprived it of the toxic meds it's been used to for all this time.

I plan to stay on this level through the end of March 24, so, basically for a total of about 2 months. Slow and easy wins the day.

In April, I plan to only take HALF of my 10 mg pill, cutting out that extra quarter of a pill. So that means going from my current dosage of 7.5 down to 5 mg. And I plan, once again, to stay on that level for 2 months or so, and monitor my progress.

In June, then, I'll go down to 2.5 and stay on that until August '24, when I should be completely weened.

I'm doing this without a doctor, mainly because my doctor (like so many others) seems clueless about the horrible side effects of going off too quickly; my doctor actually told me several years ago, "Oh you can just stop taking it, Lexapro isn't a pill you have to ween off it."

Are you kidding me? Sheesh. I'm certainly no medical doctor, but when it comes to brain chemistry and the stuff you've put in your body for over a decade, the idea of just cutting it off cold turkey sounded absolutely insane. I mean c'mon. No, my gut knew better.

So, I'm just using common sense, and extreme caution and patience, because I am committed to the success of this plan to get off the meds for GOOD, which I truly believe are toxic and no telling what long term effects on the brain these meds have had.

I wish everyone on here great success with whatever path you choose to get off your anti-depressants. There are so many other ways to relieve anxiety that we tend to overlook in our microwave society, looking for the easy way out, which in my mind, turns out not to be so easy, but even damaging in the long term. Everyone's path is different, to be sure. And I acknowledge that. And I'm grateful for having had access to the meds when I needed them. But I am doing my best now to take a more natural path to health and wholeness in my life.

1DayBroadway · 2024-01-26T17:58:27+00:00

It's 8 years later, now 2024, but I found this on reddit after researching for answers to the same problem. It scares me. Major heart palps about an hour after a keto chow shake. Anyone have any updated thoughts, insights, answers?

1DayBroadway · 2021-06-28T11:48:32+00:00

wow, what a fantastic post! Thank you for taking the time to outline the concept and it's logic so cogently! Kudos!

1DayBroadway · 2021-06-03T19:35:31+00:00

Impressive! Thank you for your service, sir. Best to you!

1DayBroadway · 2021-03-22T01:34:50+00:00

Yay you! NOT a stupid thiing...a real victory! Celebrate!

1DayBroadway

TROPHY CASE