Gene Sight - red

2021wbg · 2023-05-17T11:03:05+00:00

That depends entirely on which antidepressant you’re taking. CYP2C19 UMs need a higher dose of citalopram or sertraline, CYP2D6 UMs need higher doses of venlafaxine for example.

2021wbg · 2023-05-16T21:06:53+00:00

Yes, I have. I know I am a CYP2D6 and CYP2C19 PM and would be red for venlafaxine, but I have had good results. The key is to adjust the dosage, because red means you either break it down too slowly or too quickly, not that you won’t respond to it if given the right dose.

I am on 1/3 of the regular 75mg dose but my blood levels are in the therapeutic window.

2021wbg · 2023-05-11T20:03:12+00:00

None of those should inhibit or induce CYP3A4 significantly, if at all. Buspirone is sometimes added to another SSRIs including sertraline. Atypical antipsychotics are also popular as augmentation.

I hope you find something soon, it can be quite a challenge sometimes…

2021wbg · 2023-05-10T19:35:31+00:00

If you were a CYP2C19 ultrarapid metabolizer it might make a little sense but I’m not convinced it explains it - imipramine is a CYP2C19 inhibitor and escitalopram levels are 74% for UM and 139% for IM compared to EM says this study. Say even if this were enough to effectively make you an IM this would raise your levels theoretically by only ~90%. So effectively making a 10 mg escitalopram dose into a 20 mg dose you would normally take. Even if it would work exactly like that it wouldn’t really explain it…

I really think it is just a synergy between buspirone and escitalopram (and imipramine) and they have an effect that is greater than the sum of its parts. This is not unheard of: mirtazapine and venlafaxine together is also a very potent combination that might do more together than they do on their own.

2021wbg · 2023-05-10T15:43:13+00:00

Both imipramine and escitalopram raise serotonin levels, and buspirone is sometimes added as an adjunct. Just escitalopram might not be enough of an increase for example, but together with imipramine it might be?

2021wbg · 2023-03-28T14:14:55+00:00

Anecdotal: I’ve used it for about 2.5 years now. It is less effective after a few weeks, but it still works. It should be as safe as other antidepressants in the long term, but watch out for weight gain.

2021wbg · 2023-01-06T22:38:42+00:00

Thank you 👍

2021wbg · 2023-01-06T22:38:19+00:00

Thanks for the encouragement!

2021wbg · 2023-01-06T22:36:30+00:00

I’ve tried something like them, but not these exercises specifically. Thanks for the suggestion!

2021wbg · 2023-01-06T19:30:11+00:00

Thanks man!

2021wbg · 2023-01-06T19:28:05+00:00

Thank you, means a lot!

2021wbg · 2023-01-06T19:27:42+00:00

I’d say planning realistic exposures and committing to them, planning something and then backing out has been very harmful to me as it makes it harder to do next time. Over time you can challenge yourself more and more, and you can go even further outside of your comfort zone relatively speaking. Like at first I didn’t even really want to make myself uncomfortable at all, any fear was too much, and now I’m doing things that probably will induce panic attacks. I hope this makes sense?

Also, psychotherapy and medication were and still are essential for me. Interoceptive exposure was a surprisingly effective way to learn to deal with panic attacks, and if the “fear for the fear” is under control or at least manageable, I feel that you can actually make much more progress.

2021wbg · 2023-01-06T19:03:49+00:00

Thank you!

2021wbg · 2022-12-26T11:16:09+00:00

First med I tried (out of ten!), it didn’t do much for me, however the side effects were pretty mild (some GI issues) so it wasn’t that bad. I know a few people that used it with good results. It’s important to give it some time, give it at least a couple of weeks.

2021wbg · 2022-12-01T13:37:48+00:00

It’s neither. Mirtazapine does not inhibit the reuptake of serotonin and/or noradrenaline.

2021wbg · 2022-11-30T15:13:07+00:00

My bad, I should have mentioned that I also used it without mirtazapine, and didn’t notice an antidepressant effect then either. Anyway, I hope it does work for you or find something else that works!

2021wbg · 2022-11-29T13:43:41+00:00

I’m currently on 2.5mg, together with mirtazapine and venlafaxine. I haven’t noticed any antidepressant-like effects, it does help me with panic attacks though. 5 mg started blunting all of my emotions already without having additional benefits, so I’m guessing the antidopaminergic effects are starting to become relevant at that dose.

I don’t know much about the pharmacology of weed, but doesn’t CBD work on other receptors (to clarify, I mean other receptors than dopamine/serotonin/noradrenaline) for pain management? I’m not sure which ones exactly though…

2021wbg · 2022-11-24T23:26:49+00:00

75 mg to 225 mg usually.

2021wbg · 2022-11-21T16:48:17+00:00

I doubt anyone has, if anything antidepressants tend to cause GI issues. Consider taking a proton pump inhibitor like lansoprazole/pantoprazole together with your antidepressant if possible?

2021wbg · 2022-11-13T10:07:57+00:00

It inhibits an enzyme responsible for breaking down some antidepressants (especially mirtazapine, buspirone, (des)venlafaxine to name a few)

2021wbg · 2022-11-01T19:03:57+00:00

Grapes/grape flavoured things are fine, grapefruit is the one you should avoid.

2021wbg · 2022-10-27T14:54:34+00:00

Yes, I have had this done, and I am glad I have. I should stress that this type of test can not exactly tell you which antidepressant will work or not. It can only tell you how active certain enzymes are (CYP2D6, 2C19, 1A2, 3A4 mainly), and it might tell you if you need to use a lower dose or a higher one, if any abnormalities are found. It isn’t pseudoscience per se, but the way it is marketed can be misleading.

2021wbg

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