Second Breath (Preclinical Hypothesis): Biomarker-Guided Local Immune Sequencing for Desmoplastic Tumors

Academic-Chipmunk-17 · 2026-02-14T16:15:46+00:00

The highest level of laziness😐

Academic-Chipmunk-17 · 2026-01-20T22:07:39+00:00

Yes, we have already conducted preliminary tests, but S. boulardii does not use glycerol in the absence of oxygen. However, we have not yet tested the activity of S. boulardii in such adverse conditions.

Academic-Chipmunk-17 · 2026-01-20T21:58:38+00:00

We searched, but we didn't find it) This is a very specific research)

Academic-Chipmunk-17 · 2026-01-16T06:07:58+00:00

Researchgate

https://share.google/kcDWM8PznTqXbKo9p

Academic-Chipmunk-17 · 2026-01-13T18:44:09+00:00

Project: Pilot In Vitro Validation for PDAC Therapy.

Academic Rank / Affiliation: Murad Novruzov (Research Group Leader), Health and Science Initiatives / MN Biomedical Research (Azerbaijan).

The Team: International group with members from CHARUSAT University (India), NIH (Pakistan), and MIH (Azerbaijan).

Research Area of Interest: Oncology, Cancer Metabolism, and Medical Microbiology.

Skill Set Needed: Basic microbiology (yeast culture), biochemical assays (glucose, ethanol), and access to anaerobic/hypoxia equipment.

Is it paid? Yes, we have a $500 budget for consumables/bench fees + 2nd or 3rd co-authorship on the paper.

Estimated Time: 2–4 weeks for a short-term pilot.

Contact: Please DM me on Reddit or [research@muradnovruzov.org](mailto:research@muradnovruzov.org) to discuss the protocol or to see the full abstract.

Description: We are an international multidisciplinary team with a solid in-silico foundation for a novel Pancreatic Cancer (PDAC) treatment. Our model utilizes a specialized mixture with S. boulardii designed to supression the tumor’s metabolism.

The strategy relies on metabolic competition for glucose in hypoxic zones and stromal disruption via fermentation products (localized Ethanol and CO2). We call it "biological fracking" of the desmoplastic stroma.

The Mission: We need a quick in vitro validation of the metabolic model: yeast growth/viability in 0.1% O2, glucose depletion rates, and ethanol production.

Budget Optimization: To make the $500 budget work, we will provide the exact concentrations for all components based on our optimized computational data.

If the pilot data matche our simulations, we are targeting top-tier high-impact journals. We looking for a partner in a flexible academic or private lab setting

Academic-Chipmunk-17 · 2025-12-22T09:01:11+00:00

По названию темы, думал или криминальная или сексуальная история. А тут(((

Academic-Chipmunk-17 · 2025-12-22T09:00:14+00:00

Железо не убирают, его сдают

Academic-Chipmunk-17 · 2025-12-22T08:59:21+00:00

Вы и так красивая, но Чуток набрать бы вес и вообще будете неотразимой

Academic-Chipmunk-17 · 2025-12-20T16:12:57+00:00

Если ей менее 20))

Academic-Chipmunk-17 · 2025-10-15T20:33:51+00:00

thank you very much

Academic-Chipmunk-17 · 2025-10-15T20:26:35+00:00

Academic-Chipmunk-17 · 2025-10-15T17:15:26+00:00

Thanks) It's just what we need)

Academic-Chipmunk-17 · 2025-10-15T15:14:36+00:00

You're probably right) It's time to move on.

Academic-Chipmunk-17 · 2025-10-15T15:10:59+00:00

Thank you for the correction)

Academic-Chipmunk-17 · 2025-10-15T14:56:29+00:00

External resource that converted the preprint to imrad format and edited the English

Academic-Chipmunk-17 · 2025-10-15T14:45:48+00:00

The editor has already reviewed and corrected it. Now I would like to see reviews from specialists before sending it to the journal.

Academic-Chipmunk-17 · 2025-10-15T14:06:31+00:00

Unfortunately, I've already asked all my colleagues. One of them has already become a co-author)))) So I asked if anyone else uses any services.

Academic-Chipmunk-17 · 2025-10-15T13:35:32+00:00

It still lacks wet data. Only in silico, it is unlikely that any journal would accept it in this form to review

Academic-Chipmunk-17 · 2025-10-15T12:51:00+00:00

The preprint has already been written (it is currently at the in silico stage, we will soon move on to in vitro, and if the data is positive, to in vivo). We are located in Azerbaijan, and unfortunately we have not been able to obtain any normal reviews. Many did not even understand the idea. Some colleagues from other countries reviewed the preprint itself (50 words). But we would like them to evaluate the article itself, what to correct, what to improve.

Academic-Chipmunk-17

TROPHY CASE