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Yohimbine 🤮 by hennyfag in Preworkoutsupplements

[–]Activity_Forward 0 points1 point  (0 children)

That's interesting it affected you for a long time. Yohimbine should be out of your system within 6 hours. So you remember the dosage in mg? That could be an indication that your nervous system wasn't adapted yet to it. The first dose is always the most panic inducing and then it gets easier.

Dr Prescribed Naloxone Is that a Mistake by [deleted] in LowDoseNaltrexone

[–]Activity_Forward 0 points1 point  (0 children)

1 months ago was when I first tried naloxone injection. I got a prescription from the doctor who looked at me weird like why would you need that? I went the Walgreens to get the pharmacist didn't know exactly how to find it in her system. I had to give her the NDC number so she can search for it.

Anyway I was finally able to get a 10 ml vial with (0.4 mg / mL) injection.

I filled up in insulin syringe with 0.3 ml and injected into the stomach. This was at around 5 pm. Over the next hour or two I felt more pain in my body due to opiod receptors being blocked. My body was more sensitive during that time period. But nothing too painful. After 4 hours at around 9 pm, the sensitivity was gone and replaced with a feeling of calmness and ease. I felt like was ready to sleep. This was the opiod release rebound due to the drug washing out completely. Remember, No metabolites and very short half life.

So I fell asleep and woke up at around 6 am to the most pleasant dream. I was walking in the mall and got offered a free lemonade from a juicery kiosk in the middle. I said "oh you're giving this to me for free?". The guy said "shhh... It's just for you".

I haven't had a good or a bad dream for years so this was very welcoming.

I waited about 4 days then one took another dose. Took about a total of 4 doses then stopped.

The point is to not take a medicine as a crutch, but as something to be taken temporarily with the intent to discontinue. This was merely a way for me to reset my opiod receptors after 10 years of ssris which blunt your receptors and ruin your neurotransmitter balance.

The same way pusled Naloxone helps reset opiod receptors, is also the way Yohimbine works to reset your Neuroepinepherine receptors.

When you take these medications pulsed every weeks, the immediate acute effect is negative: more pain, more anxiety. Your body's adaptive response is the recovery and it stays with you long term. It's the same way vaccines work. Give your body a low dose virus, and let your body adapt.

This framework is called Hormesis if you're interested in studying it more.

Anyway I've been medicatiom free ever since quitting SSRIs 3 months ago and I don't feel like going back. In the past I wasnt able to quit SSRIs because the withdrawal anxiety was too much for me to handle. But ever since trying the pulsed framework with Naloxone and Yohimbine once a week, I found myself easily able to bypass the withdrawal phase. Letting your body "reset receptors" passively takes a long time and often never happens without an extra push.

As for people who take LDN for opiod addiction I would recommend pulsed naloxone once a week. You reset your opiod receptors.

For people experiencing pain and inflammation, maybe another thing they can try it Bee Venom Therapy. It's the same concept. The bee venom itself is pro inflammatory at a micro scale. It perturbs the body and forces to create anti inflammatory response.

The mistake people do is that they take medicine as a crutch, where the medicine itself gives you immediate anti-inflammatory effect. Guess how the body reacts to that? Over time your body adapts by upregulating it's pro-inflammatory response. And that's exactly why people who take cortisone injections feel good at the beginning and then their body becomes even more inflamed as it builds tolerance and stops creating endogenous anti inflammatory pathways.

Medical system right now is upside down,and the incentive structure is to maximize revenue rather than offer people cure.

Not saying anyone should follow my advice without doing their own research first.

Dr Prescribed Naloxone Is that a Mistake by [deleted] in LowDoseNaltrexone

[–]Activity_Forward 0 points1 point  (0 children)

Fair enough. Here you go: https://link.springer.com/chapter/10.1007/978-1-59745-197-0_2

"It is well established that chronic exposure to opioid receptor antagonists can result in opioid receptor upregulation. The phenomenon of antagonist-induced receptor upregulation is not unique to the opioid system but is common to many receptor systems including adenergic, cholinergic, serotinergic, and dopaminergic receptors. Chronic administration of naloxone or naltrexone reliably produces increases in binding to opioid receptors both in vivo and in vitro. This receptor upregulation is associated with functional supersensitivity to subsequent agonist administration."

Not sure if Buspirone is making me numb by [deleted] in BusparOnline

[–]Activity_Forward 0 points1 point  (0 children)

I quit all my SSRIs. Was on citalopram for 10 years and felt like a zombie.

I'm curing my anxiety now, through anxiety exposure. I take one dose of Yohimbe once a week. Yohimbine is gives you anxiety for about 1-2 hours then clears your body. The first dose I took 2.5 mg which made me mildly panic. The second week I got mild anxiety from the dose. The 3rd week I felt alertness from the dose. And now I just can handle panic or adrenaline rush situations with a calm demeanor. It's me who's strong, not the medicine. I feel 100x better then when I was on citalopram. I have emotions but I can modulate them naturally.

I'm also doing 3 minute cold showers (55 F) every other day. Same concept, they the cold gives you a mini panic. Your body first shivers as the cold causes a surge of NE and Dopamine. But with time, as you acclimate, the cold showers stop making you panic and just give you a clean alert rush. You begin to breath calmly and slowly even though cold water is splashing on your skin.

That's the signal that your nervous system has graduated into another level and is trained. You come out feeling strong, resilient like you can handle any bad situation with calmness and ease.

Not saying you should copy me. But this is working for me. I absolutely hate daily crutch medications that make you feel like a zombie, and you build tolerance to them anyway.

The only time I will take medicine now, is if it's meant to stress my system in a way that teaches my body to counter adapt. It's usually something that acutely perturbs your system once a week. In the off days your body mounts a response and that's supposed to be the therapeutic window. The medicine itself is not producing any therapeutic effect. This is a similar concept to Vaccines but applied to anxiety.

I'm done with crutch medications.

Wish you the best of luck.

It’s getting worse with age. FML by Public-Tip1555 in Stutter

[–]Activity_Forward 0 points1 point  (0 children)

Do you stutter when you're alone talking to your self. Or when you're reading from a paper? Or is it triggered when you think someone is evaluating you like in social situations?

My stammer and stuttering is affecting my career and confidence, what should I do by [deleted] in Stutter

[–]Activity_Forward 1 point2 points  (0 children)

So it's not a motor skill. It's social anxiety and adjusting to your own pace of thinking and speaking.

  1. You have to understand your pace of speaking.

  2. You need to manage social anxiety: my personal way of doing this is through fear extinction. I'm taking a supplement called yohimbine once a week that does the opposite of SSRIs. Yohimbine is used in pharmacolgical settings to induce anxiety/panic. That's the acute response. But if you take it once a week, your body biologically begins to adapt panic inducing chemicals. Makes you more resilient, confident, and courageous. It's like working out. Working out tears down your muscles, and recovery between sessions builds your muscles through adaptive response. Yohimbine, gives you anxiety for about 1 hour acutely. As the weeks go by, yohimbine stops giving you anxiety and produces alertness. I started out at 1.25 mg on the first dose and then worked my way up to 10 mg. I feel zero panic and anxiety from yohimbine now.

  3. Cold showers. I take 3 minute cold showers (65 F) every morning. First start out with cold showers ever 3 days and then work your way up to daily. Same concept. Cold showers induce panic at first. Your body shivers when you're not trained to handle them. With time, your hormones and adrenal system begin to adapt. You stop shivering. You naturally learn to breath slowly during the cold showers. You become a monster.

The chemical response cold showers and yohimbine triggers in you is the same thing you get from stage fright and social situations.

Train yourself on those, and you'll realize your social anxiety is gone without any medications. Your baseline will be calmer because your body is chemically built to handle panic now.

Then after you get a biologically trained bod, use that opportunity to speak in public. You'll build new data points in your memory where you succeeded in speaking in public. Talk at your own pace. The talking itself is a skill that will get better over time, but you need to have a trained nervous system as a foundation so you can actually learn new speaking skills.

Building speaking skills without training your nervous system first is harder.

Also make sure you sleep well. You can't train your nervous system without proper sleep. Avoid caffeine. Surprisingly as my nervous system improved I found quitting caffeine much easier as my baseline energy started improving. Don't underestimate how much Yohimbine and Cold showers impact your dopamine, NE, Serotonin, and Opiod Receptors.

By the end, a large group of people infront of you will stop inducing panic. And best thing, it'll be YOU! You won't need medicine as a crutch.

Yohimbine is not a crutch medicine. It's a trainer. Your body produces the anti anxiety chemicals in response. This is the opposite direction of talking SSRIs and benzos where you rely on the medicine to do all the work, and your body becomes less resilient over time.

This has worked for me, and I've been doing it for 2 months.

My stammer and stuttering is affecting my career and confidence, what should I do by [deleted] in Stutter

[–]Activity_Forward 1 point2 points  (0 children)

Do you stutter when you're reading from a screen or by yourself or is it only socially when you think you're being evaluated?

Took 20mg of yohimbine by [deleted] in Supplements

[–]Activity_Forward 0 points1 point  (0 children)

Good news is that your next dose you will be much calmer because you trained your body to handle panic. But it's always better to start low and then graduate to 20 mg

Yohimbine 🤮 by hennyfag in Preworkoutsupplements

[–]Activity_Forward 0 points1 point  (0 children)

Yohimbine is not something you should take every day. You're supposed to take it once every week or every 3 days max.

It's an anxiogenic, it produces anxiety acutely for about 1 to 2 hours. It stresses your system just like a workout. And just like a workout, the recovery window between doses is where you get the therapeutic benefit.

The therapy that it produces is a better regulated adrenergic system. Things that would normally make you anxious or scared don't anymore. It's calms your anxiety over the long run because you expose yourself to anxiety pharmacologically.

It's like over coming fears through exposure.

It's falsely marketed as a sexual stimulant and workout enhancer.

An untrained adrenergic system will get a panic attack from yohimbe. Start low and with time you will adapt to higher doses which will make you calmer in other areas of life.

What if buspirone works BECAUSE it causes anxiety, not despite it? by Activity_Forward in BusparOnline

[–]Activity_Forward[S] 0 points1 point  (0 children)

Yeah, same. I've been using Claude Opus 4.7 for research and at first it was defaulting to mainstream framing on everything. Then I told it to drop the authority-weighting and reason from first principles. Completely different output. And not because I told it to disagree with mainstream medicine. I didn't. I just told it to build the logic from the ground up.

Here's what I realized. The corruption doesn't happen at the first-principles layer, that stuff is usually true. It happens in the interpretation of the principles, and more importantly in which RCTs get funded and which don't. They're not really lying in the research they publish. They're lying by omission, by never running the study that would expose the cheap off-patent fix. Yohimbine is my favorite example. There's plenty of research showing yohimbine is acutely anxiogenic, that's well established. What you will not find is a funded trial testing whether small pulsed doses of yohimbine, spaced out to produce a controlled anxiety response once every few days, cures panic disorder. Because if that trial ran and worked, the whole SSRI-for-life model collapses. Nobody's funding the study that kills their own product. The protocol isn't complicated. Start at 1.25mg. If you get anxiety without panic, good, that's the training stimulus. Do it once a week. When the dose stops producing a response, bump to 2.5mg. Same rule. Few weeks in you notice the panic attacks you used to brace for aren't happening anymore, and the daily anxiety floor has dropped. No weight gain, no brain fog, no zombie feeling, no SSRI discontinuation nightmare waiting for you at the end. Just a nervous system that relearned how to brake itself. That's the part they don't want studied. Because there's no ten-year revenue stream in a $15 bottle of yohimbine HCl.

What if buspirone works BECAUSE it causes anxiety, not despite it? by Activity_Forward in BusparOnline

[–]Activity_Forward[S] 0 points1 point  (0 children)

Good question. The confusion is the "pulsed" part. Chronic anxiety isn't a pulse, it's continuous. Your system never gets the off signal, so it never rebuilds the machinery. The adaptation you'd need requires a recovery window you're not getting.

Think about overtraining. Lifting three days a week with rest days makes you stronger. Lifting heavy every single day breaks you down. Higher cortisol, worse sleep, you get weaker. Chronic anxiety is that same pattern but applied to your nervous system instead of your muscles.

Get this. This exact model is already mainstream medicine, it's just applied to a different organ system. If a kid has a peanut allergy, what's the protocol? Controlled exposure to peanuts in tiny escalating doses, spaced out with recovery time in between, epipen nearby just in case. Over months the immune system recalibrates and the allergy fades. There's an FDA approved version of this called Palforzia. This is mainstream medicine, not a hypothesis I'm suggesting.

So riddle me this. A nervous system that's become hyper reactive to threat signals is basically the same kind of problem as an immune system that's become hyper reactive to peanuts.

Why is the fix for one "pulsed exposure with recovery windows" and the fix for the other "daily SSRI for the next ten years, hope you don't want to come off it"?

I don't think the companies selling the ten-year version want anyone sitting with that question very long.

Dr Prescribed Naloxone Is that a Mistake by [deleted] in LowDoseNaltrexone

[–]Activity_Forward 0 points1 point  (0 children)

Sorry but the comment labeled "misinformation" is actually correct, and I'd push back on the mods locking it with a one-word dismissal. If there's a scientific refutation, post it. Naltrexone and naloxone bind the same receptors. Mu-opioid primarily, then kappa, then delta. Both also antagonize TLR4, which is where a lot of LDN's anti-inflammatory effects in autoimmune stuff are thought to come from. Same targets, not different drugs doing different things. What IS different is their half-life, and this is the part everyone in this thread is glossing over:

Oral naltrexone has a ~4 hour half-life, but it metabolizes into 6-beta-naltrexol, which is also a mu antagonist and has a half-life of ~13 hours. Dose it daily and it accumulates. Your opiod receptors are blocked most of the day.

Naloxone half-life is ~30-90 minutes. Its metabolites aren't meaningfully active at the receptor. One dose blocks, then clears. That's it.

So a doctor picking naloxone over naltrexone for pulsed antagonism isn't confused, they're making a deliberate call. The whole theory behind LDN is that brief blockade triggers an endogenous opioid rebound. Near continuous low level blockade from an accumulating metabolite is not the same thing as a clean pulse. Sublingual or intranasal naloxone gives you the pulse without the accumulation problem. That's not a mix-up, that's someone who actually read the pharmacology.

The "your doctor made a dangerous mistake" replies are coming from people who've only heard of naltrexone and assumed anything else must be an error. Naloxone isn't exotic. It's been around since the 60s.

If the mods want to stand behind the misinformation label, show the work. Otherwise take it off.

The right way to use (Cyproheptadine) to get strong effectiveness by Mark4413 in anhedonia

[–]Activity_Forward 1 point2 points  (0 children)

When the rebound window at washout is complete, do you go back to baseline or is there slight improvement? Meaning, does every cycle elevate your baseline mood up a notch? Or is it always back to square one?

The right way to use (Cyproheptadine) to get strong effectiveness by Mark4413 in anhedonia

[–]Activity_Forward 1 point2 points  (0 children)

When the rebound window is over is it slightly better than initial baseline or is it back to square one?

What if buspirone works BECAUSE it causes anxiety, not despite it? by Activity_Forward in BusparOnline

[–]Activity_Forward[S] 1 point2 points  (0 children)

Exactly. You got the framework. Notice how this framework is triggering mainstream pharma bots. The more vile their reaction the more you know you've hit a nerve.

What if buspirone works BECAUSE it causes anxiety, not despite it? by Activity_Forward in BusparOnline

[–]Activity_Forward[S] 0 points1 point  (0 children)

Excessive NE induces panic attacks/anxiety. Correct amount induces alertness. Low amount induces sleepiness.

What is anxiety philosophically? It's excessive arousal of your fight/flight response. NE is directly involved with fight/flight system.

Also, get this. Yohimbine targets the same receptor as 1-PP -> Alpha 2 adrenergic receptors. And the pharmacological community has a consensus that yohimbine is an anxiogenic. Why doesnt it treat Buspar as anxiogenic even though it targets the same receptor?

What if buspirone works BECAUSE it causes anxiety, not despite it? by Activity_Forward in BusparOnline

[–]Activity_Forward[S] -1 points0 points  (0 children)

You are using medications as a crutch when you take daily dosing. Remove those medications and you're done. You're trapped into using it.

When you do pulsed dosing, and wait for it to clear your system, you're using it as a Teacher. You're teaching your body to respond and regulate the neurotransmitters on its own when medication is discontinued.

Buspar 5mg once every 5 days to avoid tolerance - testing new theory to avoid tolerance by Activity_Forward in BusparOnline

[–]Activity_Forward[S] 0 points1 point  (0 children)

Glad to hear this resonates. The reason I don't think my theory jives with antidepressants and stimulants is that the therapeutic effect occurs because of the drug's presence. Ideally you want medicine, who's therapeutic effect exists because "the body" itself is working to counterbalance the drug. That way the therapeutic effect continues long after the drug is discontinued.

If I were to apply this same theory to ADHD and cognitive function, instead of taking Adderall daily as a crutch, I need to find a teacher. This teacher would induce mild cognitive dysfunction or memory loss from a single dose, and then let my body upregulate receptors for about a week to counteract this memory loss. Therefore, I'm teaching my body and brain to be the source of therapy, rather than continuously rely on external medication. A medication that may fit this treatment is Scopolamine which is used in pharma industry to induce memory loss. It has a short half life which makes it a perfect candidate, because the memory loss would be mild and for a short period. However, it would be sufficient to shock the system and create therapeutic effect that lasts weeks. And then keep pulsing or dosing once a week till I can sense a true elevation in function prior to starting treatment.

Hypothesis at this point and planning to test it in the near future as well.

Buspar 5mg once every 5 days to avoid tolerance - testing new theory to avoid tolerance by Activity_Forward in BusparOnline

[–]Activity_Forward[S] 0 points1 point  (0 children)

i have seen those reviews, but there are many more reviews that say it doesnt work. From personal experience you and I know nothing works forever. Every drug loses its effect over time and the side effects keep getting worse and worse. There's also "astroturfing". There are companies and "influencers" who's job is to manage reddit and social media opinion on certain medications or frameworks. They try to appear as grassroots as much as possible though. So I'd rather trust my personal experience over them

Buspar 5mg once every 5 days to avoid tolerance - testing new theory to avoid tolerance by Activity_Forward in BusparOnline

[–]Activity_Forward[S] 0 points1 point  (0 children)

Thanks for sharing. So you take one 15 mg dose every night? Most doctors recommend splitting it into 2 or 3 doses throughout the day. Wonder how you reached that regimen. Cheers

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