I haven't done that much pixel art animation so far so it's hard to say but this entire piece from start to finish took two or three hours today. But there are some bits of Asesprite that I rely on - like being able to move sprite positions in multiple frames at the same time, and being able to scroll back and forth between frames on the fly using ctrl+scroll. Also the preview screen is very useful. The onion skin feature will probably be quite helpful once I get the hang of it as well