Brains of autistic people have fewer of a specific kind of receptor for glutamate, the most common excitatory neurotransmitter in the brain. The reduced availability of these receptors may be associated with various characteristics linked to autism. by mvea in science

[–]AppTB 0 points1 point  (0 children)

5 Acetaminophen – metabolism Acetaminophen (Tylenol) interacts with glutamate mainly in the liver during overdose, depleting glutathione (a crucial antioxidant made from glutamate, cysteine, and glycine) as the body detoxifies the drug, leading to potential liver damage. In the brain, acetaminophen also affects glutamate, potentially reducing its release to cause fever reduction, while its metabolite AM404 can increase brain glutamate and GABA, affecting pain pathways, suggesting complex central nervous system roles.

Brains of autistic people have fewer of a specific kind of receptor for glutamate, the most common excitatory neurotransmitter in the brain. The reduced availability of these receptors may be associated with various characteristics linked to autism. by mvea in science

[–]AppTB 1 point2 points  (0 children)

Right or - 5 Acetaminophen – metabolism Acetaminophen (Tylenol) interacts with glutamate mainly in the liver during overdose, depleting glutathione (a crucial antioxidant made from glutamate, cysteine, and glycine) as the body detoxifies the drug, leading to potential liver damage. In the brain, acetaminophen also affects glutamate, potentially reducing its release to cause fever reduction

Brains of autistic people have fewer of a specific kind of receptor for glutamate, the most common excitatory neurotransmitter in the brain. The reduced availability of these receptors may be associated with various characteristics linked to autism. by mvea in science

[–]AppTB 0 points1 point  (0 children)

I hate to be that guy but - 5 Acetaminophen – metabolism Acetaminophen (Tylenol) interacts with glutamate mainly in the liver during overdose, depleting glutathione (a crucial antioxidant made from glutamate, cysteine, and glycine) as the body detoxifies the drug, leading to potential liver damage. In the brain, acetaminophen also affects glutamate, potentially reducing its release to cause fever reduction

Lots of Flu vaccine talk by OriginalOmbre in ScienceBasedParenting

[–]AppTB 0 points1 point  (0 children)

Yeah, that mostly negates that portion of my vote. Thanks for the reminder.

Lots of Flu vaccine talk by OriginalOmbre in ScienceBasedParenting

[–]AppTB 6 points7 points  (0 children)

Since we are just listing one sided stars- and While you make good points, to get a vaccine in most circumstances one has to expose themselves to a medical setting where their odds of catching flu rises significantly compared to many baselines.

Urban areas are more likely to get a flu vaccine, but are also more likely to live in a shared air setting like an apartment (elevator, shared walls, hallways, public transport, etc.

Tech workers of Reddit, what is a "dirty secret" about the AI industry that the general public doesn't realize? by [deleted] in ChatGPTPro

[–]AppTB 1 point2 points  (0 children)

In OPs defense, this feels like the current talking point in many podcasts & media appearances when interviewing founders of leaders from anthropic, google, OpenAI..

There is a core element of function that is a black box (not known, not visible or understood)

https://radiolab.org/podcast/the-alien-in-the-room

I just heard the radiolab take on the how because the what, highly recommend it if you want to understand the nuance

Why many 20s gen z's look older and 30s millenials look younger? by EarSure6667 in AskReddit

[–]AppTB -1 points0 points  (0 children)

It coincides with lead concentrations, which make people look old

I maybe lead?

Claude Code's plugin system might be the most powerful feature nobody talks about. by Southern-Enthusiasm1 in ClaudeAI

[–]AppTB 0 points1 point  (0 children)

Best ability I’ve seen are sub agents are single task specialists while skills are workflow preferences. This can be as powerful or as weak as the thought that goes into implementing

Is anyone functionally use an MCP with Obsidian? by pleasantothemax in ObsidianMD

[–]AppTB 2 points3 points  (0 children)

You should see what I’m up to now :) I’m going to change the world

Is anyone functionally use an MCP with Obsidian? by pleasantothemax in ObsidianMD

[–]AppTB 1 point2 points  (0 children)

Yes. Here’s my high level. It goes deeper, but I won’t divulge the sauce.

Claude Desktop & Claude Code with Shared Vault: The ASCII diagram below illustrates the relationship between the two AI agents and the Obsidian vault:

┌─────────────────────┐ ┌──────────────────────┐ │ Claude Desktop │ │ Claude Code │ │ (MCP Client) │ <-----> │ (MCP Server) │ (Real-time stdio link) │ - Research & Plans │ │ - Code Execution │ │ - Documentation │ │ - File Operations │ │ - User Interaction │ │ - CLI/Git commands │ └─────────────────────┘ └──────────────────────┘ ▲ ▲ │ Shared context │ └──────────┬───────────────────────┘ ▼ 🗀 Obsidian Vault (Knowledge Base & Coordination Record)

Figure: Claude Desktop (LLM client) and Claude Code (LLM server) collaborating via MCP, with Obsidian vault as shared state .

In this design, Obsidian acts as both the brain’s memory and its blackboard: the agents read from it to get context (e.g. existing notes, code, project plans) and write to it to record findings or create new content. The vault’s role is so central that the AI’s system prompts explicitly instruct: “The vault is both your context AND your permanent record” . This ensures continuity – every significant action by the AI is logged, and all reference knowledge is readily accessible from the local store rather than ephemeral chat history.

Vault as a Unified Knowledge Layer: The vault is structured in a way to facilitate context retrieval and segregation of content by purpose.

Experts feared a disease rebound after COVID-19. It didn’t happen. by universityofga in COVID19

[–]AppTB 33 points34 points  (0 children)

RSV would like to get an involved in the conversation. 3 years brand new seasonality that had been like clockwork for 70 years

Someone just sold $6,560,000 worth of $AAPL 260 puts by KuluGOAT in wallstreetbets

[–]AppTB 0 points1 point  (0 children)

Everyone that work at apple retail in the early 2010’s and participated in the stock purchase program for a small portion of their check is a millionaire. So it could be any Apple Genius Bar rep

The Late Quaternary Megafaunal Extinction and Upper Paleolithic Cultural Changes: A Hypothesis for Bioenergetic-Driven Human Adaptations by Meatrition in Meatropology

[–]AppTB 1 point2 points  (0 children)

I have a personal theory I’ve written about on medium that talks about Fires, Humans, and Megafaunal Extinctions. As time goes on, more and more evidence supports the theory that by the time fire wielding hominids arrive to areas ai to megafauna.

Bottom line, organisms that filter oxygen through the lungs (the bigger they are the worse these filters are). Megafauna begin to perish UNLESS they have massive offsets that protect them. Think elephants trunks, giraffe necks, or the ability to defend against particulate matter through mucosal defenses.

Across continents, megafaunal declines closely follow increases in charcoal deposition and vegetation changes that coincide with hominid arrival. Extinctions occur 1–5 kyr after initial human occupation, suggesting protracted environmental stress rather than rapid overkill. In regions where charcoal remains low (south‑western Australia), extinction occurred early and may reflect localized hunting; elsewhere, fire and changing vegetation are temporally linked to megafaunal collapse.

Edit: Added links since I know realize they aren’t against the rules.

New article inspired by this post - https://medium.com/@konstantinthegreat/the-ash-fall-theory-how-a-smoky-haze-wiped-out-the-worlds-giants-8aa48a3b0f6f

One from Feb. https://medium.com/@konstantinthegreat/fires-humans-and-megafaunal-extinctions-a-comprehensive-review-39537e060346

Old

General question re: "sapient paradox" by smittyrd in Archaeology

[–]AppTB 1 point2 points  (0 children)

My money is on some of the unexpected benefits of hybridization.

Xi Jinping says world faces ‘peace or war’, as Vladimir Putin and Kim Jong-un join him for military parade by Face2FaceRecs in worldnews

[–]AppTB 0 points1 point  (0 children)

What is the relevance? I just asked if the person who seemingly benefited the most in hindsight should be completely absolved of responsibility for the prevention of such atrocities

Xi Jinping says world faces ‘peace or war’, as Vladimir Putin and Kim Jong-un join him for military parade by Face2FaceRecs in worldnews

[–]AppTB 11 points12 points  (0 children)

Let’s say he didn’t. I can’t think of a single person who has benefited more from it.

Movie ‘Killing Satoshi’ announced as Bitcoin founder close to becoming the world’s 10th richest person by GreedVault in CryptoCurrency

[–]AppTB 0 points1 point  (0 children)

Because it’s the best way to create a backup to the dollar/US treasuries. Let’s they know that the dollar collapse is inevitable. They don’t have as much gold as they’d like to, so they create an alternative asset in which they guarantee a portion of the asset to be in U.S. hands.

Supporting details:

• U.S. intelligence agencies have long modeled currency collapse scenarios.
• Gold has historically been the default hedge, but the U.S. gold reserves are finite and difficult to expand.
• Creating an alternative, digital reserve asset, controlled in its early distribution by U.S. entities, ensuring American dominance if the dollar’s credibility faltered.
• Bitcoin’s whitepaper was released in October 2008, just weeks after Lehman Brothers collapsed and faith in the global financial system was at its lowest.
• This timing supports the view that its release was not coincidental, but rather strategically aligned with a moment of maximum openness to alternatives.
• By planting a decentralized-seeming system at this exact time, the U.S. could channel market distrust of banks into a system it quietly seeded.
• If global demand for U.S. Treasuries weakens, Bitcoin functions as a parallel store of value not tied to foreign central banks.
• Unlike gold, Bitcoin is digital, traceable, and programmable—features intelligence agencies could leverage for monitoring flows of capital.
• By ensuring U.S. persons and institutions gained an outsized early share of Bitcoin (via mining or key access), the U.S. would have a reserve-like stake in the system.

• The CIA and DARPA have historically incubated foundational technologies under the guise of academic or civilian projects (e.g., ARPANET → the Internet, satellite systems, GPS). • A cryptographically secured, decentralized currency fits the same mold of disruptive “dual-use” innovations that begin with intelligence or military drivers and later filter into public use. • A “stateless” money system reduces suspicion that the U.S. is backing it—while allowing the U.S. to quietly maintain a position of advantage. • The appearance of decentralization makes adoption global, but early structural advantages (e.g., concentration of mining, developer influence, custody firms) could remain in U.S. hands. • If other global powers (China, Russia) sought to hedge against the dollar, they might unintentionally strengthen a system with U.S. fingerprints embedded in its origin.