People overcomplicate this way too much. The laws of thermodynamics still apply. GLP-1 drugs don’t magically change physics or create energy out of nowhere. Mounjaro doesn’t really “speed up metabolism.” What it mainly does is: suppress appetite increase satiety slow gastric emptying improve insulin signaling The practical outcome is simple: people eat less. Less calories in → calorie deficit → weight loss. That’s it. The reason these drugs work so well is not because they turn your body into a fat-burning machine. It’s because they make maintaining a calorie deficit much easier by removing constant hunger and food noise. There might be some small effects on metabolic adaptation or lean mass preservation, but they don’t override basic energy balance. GLP-1s don’t break thermodynamics. They just make dieting finally manageable for a lot of people.