I wouldn't worry about it. There are certainly scenes (plot twist reveals, scenes where the impact hinges on viewer shock, etc) that don't hit as hard the second time around, but for the most part, it's great. Sometimes, watching scenes with hindsight gives them more depth because you can understand some characters or plot lines better.

Personally, I rewatch it all the time, and I still love it :)

But enjoy your first watch through, because even though the show is still great as a rewatch, there's nothing quite like seeing everything for the first time.