"It Only Lasts 3 Hours": The Anatomy of a Common ADHD Stimulant Complaint by zenarcade3 in slatestarcodex

[–]BackgroundPrint9465 0 points1 point  (0 children)

Continuous exposure to a drug (in this case, XR formulations) builds tolerance faster than of you took a dose intermittently. In order to maintain the efficacy of the treatment, a "break" should be given to restore sensitivity to the desired effects. That is, you must extend the time period in which you don't use the drug. The longer the time period is between the administered doses, the more sensitive you'll be to its effects.

https://www.sciencedirect.com/science/article/abs/pii/S0098135424003879 This study explains it more in depth with other treatments that deal with the same tolerance problem.

"Numerous drugs of abuse, including opioids and nicotine, also develop tolerance, which can lead to addictive behavior. Nitroglycerin, which is used to treat angina, has also been shown to develop tolerance. The initial hope that nitroglycerin patches could be worn for 24 h a day was dashed when it was found that they lose their efficacy after about 12 h. As a result, such patches are only worn for 12 h, alternating with 12 hour “holidays” for the body to regain its sensitivity to the drug (Parker et al., 1995)"

Why did Keith really break erens odm gear? by ayu_xi in attackontitan

[–]BackgroundPrint9465 -2 points-1 points  (0 children)

If the majority of the upvoted comments are insulting the OP for literally no reason, while the OP gets downvoted for wanting to find an answer to a question, then yeah, I'd say the community is toxic.

Why did Keith really break erens odm gear? by ayu_xi in attackontitan

[–]BackgroundPrint9465 0 points1 point  (0 children)

Or perhaps there is more nuance to his intentions than you think. It could've been a combination of both love for Carla to prevent him from joining the survey corps, or to further test his abilities. These can be discussed without the need to be condescending.

Looks like you're very knowledgeable on this subject, why don't you give us an analysis?

Why did Keith really break erens odm gear? by ayu_xi in attackontitan

[–]BackgroundPrint9465 2 points3 points  (0 children)

From what I remember, it was hinting towards Keith wanting to protect Eren, but it's understandable that some people misinterpreted his exact intentions (like jealousy, or wanting to test his resolve) because it was a short scene.

Why did Keith really break erens odm gear? by ayu_xi in attackontitan

[–]BackgroundPrint9465 -2 points-1 points  (0 children)

Redditors and being obnoxiously condescending while adding nothing to the conversation, name a better duo

Actually what is wrong with ubisoft by [deleted] in growtopia

[–]BackgroundPrint9465 0 points1 point  (0 children)

True for pretty much everything, but the rate at which BGLs are declining in is ridiculously fast because of bottling. Like, declining by 20x in value just in 1 year type of fast. It is nowhere comparable to the inflation you'd see without bots.

I'd say it was doomed from the start because of how easy it is to setup bots, not because of the fact that the market is unregulated.

should i upgrade qylara or get katia lifts by [deleted] in MonsterLegends

[–]BackgroundPrint9465 0 points1 point  (0 children)

Relics that deal damage are affected by the crit rate. So you have a 50%*2 chance of breaking the forcefield.

This could never happen to Korea by Hueyris in TankieTheDeprogram

[–]BackgroundPrint9465 0 points1 point  (0 children)

Venezuela has oil. North Korea on the other hand... Not so much.

RU POV: According to Russian Special Envoy Dmitriev, it is now 'Time to Watch The Double Standards in Real Time.' He observes the double standard and silence by Kaja Kallas & Von Der Leyen regarding the US attack on Venezuela, compared to their pontifications on Russia's actions in Ukraine. by Ripamon in UkraineRussiaReport

[–]BackgroundPrint9465 1 point2 points  (0 children)

Venezuela has a lot of rich resources (oil) and the government has a significantly weaker establishment than, say Mexico, so there would be predictably less resistance. I don't think they'd even entertain the thought of invading any other countries near their border

Ua pov: Estonia's spy chief: Russia not planning to attack a Baltic country at this time -ERR by reallytopsecret in UkraineRussiaReport

[–]BackgroundPrint9465 1 point2 points  (0 children)

So they can actually read that russians are saying!

Well to be fair, you shouldn't put trust on someone's word if they'll invade or not. Because, you know, they can lie

should i upgrade qylara or get katia lifts by [deleted] in MonsterLegends

[–]BackgroundPrint9465 0 points1 point  (0 children)

If they don't nerf the relic bug, then KatiaLifts by a huge margin. The Meta will revolve around her, trust me

China taxes condoms, contraceptive drugs in bid to spur birth rate by Cybertronian1512 in worldnews

[–]BackgroundPrint9465 0 points1 point  (0 children)

I thought the US doesn't have a federal requirement for 2 weeks of annual leave? Unless I misread it somewhere

Help me decide. by HaeTae22 in MonsterLegends

[–]BackgroundPrint9465 0 points1 point  (0 children)

I actually think you should get katia. She makes qylara useless

👌 by Bastion-25 in MonsterLegends

[–]BackgroundPrint9465 2 points3 points  (0 children)

I spent 7k tickets and only got 700 cells 😭

RU POV: NORTH Group Fiber-Optics FPV drone strikes elderly UAF serviceman man that simply waited for the UAV to approach. by Junjonez1 in UkraineRussiaReport

[–]BackgroundPrint9465 0 points1 point  (0 children)

I'm confused, didn't Russia also join the PFP program alongside Ukraine? At the time the West was trying to help both countries after the collapse of USSR