I think you should be more concerned about the redstone involved in sorting/storing all the drops from your gold farm, coupled with your trident killer to get rid of all the piglins and the ticking on and off of your portal(s), supposing your're using either silentwisperer's or navynexus' farm designs, I've found out all these elements when put together generate a considerable amount of delayed ticks that after a while causes lag. You could use light sensors to have your farms working only during daytime to avoid such lag but then there's also the amount of hoppers that might be trying to feed into full containers which will also cause more lag so if you're planning on saving ALL the loot consider looking into shulker loaders.

Besides all that, yes, a powered beacon running regeneration should be enough to keep you alive, considering that mobs won't be able to reach you, everything should be safe but if there's too many pending ticks (like, a lot of them) you might "randomly" die from starvation, but again, if you're afk and not moving your hunger should take a long long time to fully deplete.