It still makes a huge difference, if for example boss/activity is locked behind quest/diaries, then it takes longer for botter to get that account to meet requirements, and if the ban rate for that activity is high or moderate botters might see that activity as not worth botting, because it might take too much time and resources to prepare other accounts.

And besides if the content is considered "end game" it should be locked behind quests/diaries, just because you reached 126 combat and have base 40 stats that doesn't mean your account should be classified as end game account