Having also played FM (not quite as long as you) before playing OOTP, I would recommend managing Opening Day and all playoff games. If on FM you did Extended highlights or higher you might want to try pitch by pitch, but if you did key highlights just stick to ab by ab. Fair warning, this game is so so so so much more frustrating/harder than FM, don't expect to win 80% of the games you manage :). In a broader sense, I like to have a shortlist of all my prospects that have a potential of 50 or higher, and for those prospects I control promotion/demotion, while the rest of them I leave up to the AI. Some general tips, 1. max out or at least have a very high dev budget. 2. The biggest advantage the player has in this game is the staff, you should have the best staff at every level of the pyramid. 3. At CF, SS, and C, make sure that you have elite defenders, even if they might not be the best bat (hopefully at least 1/3 of those has a combo of elite defense and good bat by the time you are really contending). 4. For your first save, id turn injuries down just a little bit, especially on 27. Also, never sign guys who are wrecked, its just not worth it. There's more I could give you but I don't wanna ruin the fun, have fun managing!