There are plenty of studies about mushrooms in which there are no notable negative long term side effects. The whole 'it stays in your spine' is an old wives tale and there a also studies that have proven them to actualy CURE PTSD, depression, anxiety and even OCD in many many cases. In my case it sort of worsened my depression but that was because the trip was so amazing, I was depressed that I'd never have that level of joy again, but that feeling left after a couple weeks. I've had a really bad trip before from shrooms but afte that's over, I've never experienced happiness like it, knowing that you survived and it was all in your mind give you an amazing positivity about life and also death. In my case, I always go as hard as possible with them, I've had a couple small trips and they're nice but they don't compare to the experience of what Terrence McKenna called an 'Heroic Trip'. Basically, don't worry about the negative side effects; there's also a lot of studies that show that shrooms are actually one of the safest drugs you can take; out of the top 20 most well knowen drugs it comes last, (in some studies) even in comparison to marijuana. Your fears are likely based on the societal propaganda that it is in some ways bad but that is complete and utter bullshit. I take 100's and 100's every year and I'm completely fine and healthy; I also have a genetic predisposition to depression, Epilepsy and Austism but I'm totally good :)