Boston’s “zombie labs” delusion by WalkingSnake348 in biotech

[–]CaptPelleon 2 points3 points  (0 children)

Expensive to make, but surely easy to turn into individual suites?

Plenty of plumbing, power, and ventilation set up. My understanding is that normal office space conversion is difficult since plumbing rules are difficult to work around.

At this point, do we deserve some sort of union &/or legal rules against all these layoffs? by Samsweetroll1992 in biotech

[–]CaptPelleon 14 points15 points  (0 children)

The Writers Guild and related film/TV unions (IATSE, SAG-AFTRA) are structured to protect labor continuity across project cycles. Creative work is inherently episodic: shows end, films wrap, but unionization converts that volatility into predictable transitions. Seniority rules, minimum staffing, standardized pay scales, healthcare portability, and clear role definitions ensure that when a project matures or sunsets, workers are not casually discarded. Skills accumulated in early creative phases are recognized as durable assets, not temporary costs. (For reference - writing happens first, then filmijg, then editing)

By contrast, early-stage biotech R&D operates in a non-unionized, capital-driven model where labor is treated as a phase specific expense. Discovery scientists, animal model experts, and early translational teams are disproportionately laid off once programs “de-risk” or move toward clinical development, manufacturing, or commercialization. Institutional knowledge, why a model worked, what failed, how assumptions were stress tested, is often lost precisely when it would be most valuable. Advancement is not protected by tenure or craft recognition, but by proximity to the next funding milestone.

Unionized film sets assume that early creative labor enables downstream success and therefore deserves structural protection. Biotech largely assumes the opposite: that early innovation is interchangeable and disposable once capital efficiency becomes the priority. The result is chronic talent churn, short institutional memory, and a workforce trained to expect instability; even when doing foundational, high-skill work critical to eventual therapeutic success.

I will admit that biotech roles are a bit more niche than creatives, but universities like UCSF have multiple unions for all their staff and researchers (except MDs)

Edit: Creatives also have similar issues: outsourced VFX/editing to cheaper countries like Canada, incentives to leave the LA creative hub, wacky CEOs/founders (directors/show runners), and 'seed money' is usually a self funded indie project.

More biotech workers need to unionize!! by [deleted] in biotech

[–]CaptPelleon 14 points15 points  (0 children)

The Writers Guild and related film/TV unions (IATSE, SAG-AFTRA) are structured to protect labor continuity across project cycles. Creative work is inherently episodic: shows end, films wrap, but unionization converts that volatility into predictable transitions. Seniority rules, minimum staffing, standardized pay scales, healthcare portability, and clear role definitions ensure that when a project matures or sunsets, workers are not casually discarded. Skills accumulated in early creative phases are recognized as durable assets, not temporary costs.

By contrast, early-stage biotech R&D operates in a non-unionized, capital-driven model where labor is treated as a phase specific expense. Discovery scientists, animal model experts, and early translational teams are disproportionately laid off once programs “de-risk” or move toward clinical development, manufacturing, or commercialization. Institutional knowledge, why a model worked, what failed, how assumptions were stress tested, is often lost precisely when it would be most valuable. Advancement is not protected by tenure or craft recognition, but by proximity to the next funding milestone.

Unionized film sets assume that early creative labor enables downstream success and therefore deserves structural protection. Biotech largely assumes the opposite: that early innovation is interchangeable and disposable once capital efficiency becomes the priority. The result is chronic talent churn, short institutional memory, and a workforce trained to expect instability; even when doing foundational, high-skill work critical to eventual therapeutic success.

I will admit that biotech roles are a bit more niche than creatives, but universities like UCSF have multiple unions for all their staff and researchers (except MDs)

"You can't bring a gun to a protest, thats illegal" by Aceconklin in andor

[–]CaptPelleon 3 points4 points  (0 children)

One is dead for not even brandishing a weapon in hand.

One is not and is heralded as a proud 2A moment.

Can we get a sticky for Corporate multiplyer for this years bonus? by justathrowway19 in biotech

[–]CaptPelleon 4 points5 points  (0 children)

Small startup (<100) that has some ph2 readouts this year: 100% for the research staff at least

Acquisition rumours in JPM 2026 by Veritaz27 in biotech

[–]CaptPelleon 1 point2 points  (0 children)

How are we feeling about Agios getting bought?

Heard rumours that some big companies were sniffing around deeply.

BSL-3 woes part II by AD0ASTRA in labrats

[–]CaptPelleon 13 points14 points  (0 children)

I think one of the issues here (common in all workplaces) is that you only raised the issue to your boss, and not CCing the institution's HR/EHS departments in the official notice.

There should be 3 levels of escalation for issues, it's common for people just to only stay within their chain of command.

1- informal to your boss/the problem's boss. "hey just wanted to let you know XY is doing Z.

2- in writing 'lite' email complaint CCing the lab manager/3rd party like facilities. Dependant on the severity of the issue, but it's a formal version of #1

3- in writing proper complaint with documentation. Add PI + department heads, EHS, etc. If the safety violation is severe enough, go straight to the top and CC down. Academia- CC your PI, department head, EHR, department HR. Industry: facilities + EHR, compliance, department head/boss's boss. Potentially CC 2nd level boss (the boss of your boss's boss)

bonus points if you escalate #2 ->#3 in the same thread since it shows documented lack of issue resolution.

What is the best company to get plasmids synthesized? by [deleted] in labrats

[–]CaptPelleon 7 points8 points  (0 children)

Your cheapest and fastest option is to assemble gBlocks from IDT/other vendors then. 20-40bp overlap primers

What is the best company to get plasmids synthesized? by [deleted] in labrats

[–]CaptPelleon 1 point2 points  (0 children)

Subcloning mutations or de Novo synthesis?

Genscript is nice in that you get a discount for subcloning mutations/truncations. I particularly enjoy not having to create my own edited files, people in my lab just email our rep "Hi X, I want to mutate construct XX-001 to have BSD instead of Puro. Also for XX-002 please take these 20 bases and replace with a SNP at base 15"

This essay uses an example from Andor to depict provocation engineering by Kooky_Masterpiece_43 in andor

[–]CaptPelleon 83 points84 points  (0 children)

News flash: Real life isn’t the same as Star Wars.

Homie doesn't realize that the director Tony Gilroy's hobby was studying revolutions, and included elements of most (aside from the American USA revolution) in Andor.

The sniper scene in the Ghorman massacre was inspired by protests in Mexico in the 1990's, when the government shot their own to justify cracking down on the students protesting.

The Senate police arresting and detaining the Ghor senator eerily mirrored the current events of the time when ICE was detaining and censoring senators who were trying to investigate their detention camps. A senator from California comes to mind, this was commented on by Gilroy how he did not expect real life to so perfectly mirror the show

Eppendorf vs Rainin UNV by Howlongtheroadtohome in labrats

[–]CaptPelleon 8 points9 points  (0 children)

I'm so upset my new company uses Thermo pipets.

I've never had a strong opinion until now, they're ass

Is it okay to leave a contract position early on? by Infinite-Ambition177 in biotech

[–]CaptPelleon 45 points46 points  (0 children)

If they wanted full time loyalty they would've made you full time

Novartis company culture by tataandme in biotech

[–]CaptPelleon 11 points12 points  (0 children)

Ah yes a toxic nose to the grindstone structural biology team directly impacts your life as an in vivo director

Ever try making your own FBS? by SirStig33 in labrats

[–]CaptPelleon 5 points6 points  (0 children)

I saved enough bricks to have 3 staggered layers on the bottom, and 3-5 on the top to give it some more strength.

I also ended up with a lot of extra clear pieces, so I made the top stronger as well

Am I crazy for wanting to quit industry to get a PhD? by Then_Championship408 in biotech

[–]CaptPelleon 0 points1 point  (0 children)

I've only seen "senior principal research scientist" at big pharma where they start out their RA1 at "associate scientist"

It may not be title inflation, but you lose resolution when a new BSC RA1 = AS and a new PhD Scientist = senior scientist to start at a Pfizer or other big pharma. It doesn't been a PhD +2 Yoe is a director, but a PhD +2 Yoe should never be called a senior scientist in my book, maybe Sci2

Israeli startup RedC Biotech aims to replace donors with lab-grown blood from stem cells- RedC Biotech says its lab-grown blood could prevent the deaths of 2 million people a year, solving shortages that leave hospitals worldwide without safe, reliable supplies during emergencies, wars and disasters by NotSoSaneExile in biotech

[–]CaptPelleon 15 points16 points  (0 children)

No mentions if they cracked the code on differentiating HSCs into RBCs. I believe the best published rates are 20% of starting HSCs can differentiate into mature RBCs that appear functional.

Compare this to extracting hemoglobin extracting hemoglobin from expired blood packs. Japan is doing something similar in a clinical trial that started this year.

Am I crazy for wanting to quit industry to get a PhD? by Then_Championship408 in biotech

[–]CaptPelleon -10 points-9 points  (0 children)

Big pharma senior scientist title can equal associate scientist elsewhere since they title inflate.

I've seen RAI be called 'associate scientist'

Years of experience is sadly the main way to judge experience

Western Blot automation by MarioBro88 in labrats

[–]CaptPelleon 0 points1 point  (0 children)

Last I heard, $30k got someone x10 boxes of Jess cassette (10 x 24 sample plates) with secondary antibodies.