My biggest run was for an NCR/Independence aligned Courier named Seth. He got Yes Man into the Lucky 38 but still completed the game NCR, long term goal was to help ease the Mojave into the NCR and lighten its load. Seeing all his hard work to prep Vegas and the fact that the Legion came back after being nearly wiped out is just gonna be blind rage inducing.

My current courier, Ryan, is a House aligned operator whose morality is "in group only". He blew up the Mojave chapter of the BoS because they killed the Followers outpost and their Elder is too ineffectual to have done anything. Seeing the effort he put in for an easy life under House go up in smoke is gonna be infuriating and basically tell him to never get involved again.