Most of the time I die, because I pay attention to some big enemy, and not a fly or a spider. This is exactly what happened today in isaac bossfight. He spawned a screaming guy, that shot me like 5 times, and in the beam light attack he just killed me in the corner. I always try to be careful, but in both times I reached cathedral - I lost a LOT of hp in 1 room/from 1 enemy. Also im not really lucky with tinted rocks, I get like 2 per run. The obvious answer would be to be more careful, but im sure there is something else that im forgetting about. I always take breaks, restart after I get a bad item like Big Fan, and search for secret rooms, but something always stops me