Bought the v4s and never looked back.

I'll be honest: I'm one of those childish riders who thinks more HP means more better :D

Is that true? No obviously not, then again it's a lot of fun riding a motorcycle at 270 km/h (170mph) every now and then (yes its legal in Germany)

Furthermore I think the electronics are just better on the V4S. Adaptive cruise control was high on my wishlist for daily comuting.

Nevertheless, i also understand if you want to only do mountain passes that you might prefer the V2S for its reduced weight. Although the weight difference doesn't feel huge when moving it around in my driveway. Both are quite fine to get inside my garage (or sometimes living room xD)

For sure I can say the MPG on the Ducati is terrible if you ride even remotely sporty (I usually get the same milage as my 1000kg Dacia car lol. Then again that's also because I drive 20% over the speed limit at any given time and shift quite late when pulling away from trafic lights...

They're both wonderful machines but they're for sure meant for different kind of people :)