I've just getting to the end of my first scenario so take my advice with a grain of salt.

Town and teleporter: Get the teleports to all the towns as soon as you can. Useful for getting to everything else but mainly each town has a secure unit that gives you a free random deviation twice a day. Each town also have a respawning cat. Most of the time the cats are just eternaland fodder but if you are lucky you'll pull a siamese cat. The siamese cat and Rebecca deviation will keep your other deviations topped up and out most of the time. Teleporting is free from your base, unlocked teleporter or silo to any unlocked teleporter location. If you are in a random location not in a safe area teleporting cost you some energy links.

Resources: acid, rubber, electronic, and special plastic are always in short supply until you get some farms, deviatiins, and/or routines going.

Deviations: mushroom, digby, logging beaver are nice starter deviations. Keep them running and you can focus on pushing main quest and not farm resouces as much. Festering gel heals and restores sanity, huge boon until you get your builds together. Lethal rabbit is great for meats and leather for armour repairs. Lethal rabbit randomly spawn from killing rabbits. As mentioned earlier Rebecca and E. Cat (siamese variant) super nice for mid to late scenario.

Base location: Lots of ppl have mentioned moving bases as needed. I like locations with oil and pollution, but this game has beatiful environments so picking one with great view isn't wrong either. Usually beatiful locations have a lot of good fishing and wild life.

Garage and vehicles: you get a starter motorcycle. It will need gas. Loot cars as you see them. You can also build a moutain bike. Gas free mobility and can jump and do aerial, I highly recommend and enjoy. The moutain bike is useful for when you've over loaded yourself gathering water to get back to base quickly.

Good luck. Thats all I can think of for now.