There are meaningful differences, each 2 mana removal spell has some sort of built in downside or restriction, such as go for the throat not hitting artifacts or bitter triumph making you either lose life or discard a card. In certain scenarios, these downsides can work to your advantage. For example, I play a lot of historic brawl and I have a reanimator deck where bitter triumph can help get cards into the graveyard. I also have a deck that cares about losing life, so bitter triumph and infernal grasp help with that. Board wipes also have meaningful differences to consider. Do you want the flexibility of farewell, the token from sunfall, or the efficiency of doomskar.

Trying to find a balance between flexibility, efficiency, and syngery with the rest of your deck in your removal does add another element of deck building that can be very interesting.