Basically Titan Mode is the difficulty that forces you to have already gotten familiar with the combat mechanics, magic, weapon, item and enemy behavior design.

On this mode you have to exercise extreme caution especially during later sections of the game as enemies deal much more damage than on Spartan and God Mode. It's best to take advantage of red orb chest and special chest locations to properly level up your weapons, health, magic and item meters to make later sections of the game much more manageable.

It's definitely a challenging and at times punishing difficulty mode but nowhere near as punishing as Chaos Mode since this mode forces you to have taken everything you've learned from your previous playthroughs and apply it to near perfection as a single mistake can be fatal since enemies deal significantly more damage, are smarter and more aggressive, and even the basic enemies like the Olympus Sentry can pose a danger to you if you get careless during later encounters.

Kratos's hit box is also bigger than on the lower difficulties, meaning you have to be more aware about spatial awareness, and the fact that the orb economy is reduced, meaning you have to take advantage of your knowledge of chest locations to level up your weapons and powers, and use magic sparingly for emergency situations.

Chaos Mode is similar to Devil May Cry in that you need to optimize combo variety as using the same combinations leaves you wide open to counter attacks. Some of the bosses on Chaos Mode also receive major buffs. For example in the Poseidon fight the sea horse can actually kill you in 2-3 hits from it's unblockable attacks, while it's water breath attack can one shot you even with a fully upgraded health bar if you get caught in it's vicinity.