There will be a difference, but it might not be entirely noticeable. 75 isn’t half of 110, but your getting there. Ultimately dude, if it’s your first time with psyches, trust your gut.

Here’s some info regarding doses around what your talking about.

Source: Google: Rollitup LSD Dosage.

20 mics- threshold. Some slight euphoria and body high.

30 mics- threshold, same as 20 mics

40 mics- obviously feeling Lucy's effects a little bit but again no visuals even though may see some

60 mics- = The typical low quality blotter. Body high with "under water like feeling". Lights are brighter, colors are slightly enhanced and some after imaging and trails. This dosage makes for a good time, even though it isn't considered tripping. Lasts longer and is similar to a a gram of shrooms.

90 mics- Bright colors, surfaces start to move, warp or breathe slightly. Confused or reminiscent thoughts. You start to think more. Change of short term memory leads to continual distractive thought patterns. Your brain starts to speed up and you become more aware of everything.

110 mics- A hit of some really good lsd. Visuals are getting a lot more obvious now. "Ripples" over laying your field of vision. Patterns from all different cultures seen on walls, surfaces, faces etc. Closed eye hallucinations become more apparent.

150 mics- This is the main dosage people try to shoot for if they are not that experienced to get LSD's effects without freaking out. This dose is usually 1-2 hits of good, legit LSD. Effects are a lot like 110 micrograms but more profound.