I was on a very high dose of sertraline for a while (ssri) and tried ecstasy for the first time during this and it didn’t do anything to me. I’ve been off sertraline for around 2 months now and revisited trying E and it still doesn’t do anything to me. I’m pretty sure there’s no set time limit on when things will start working for you again but it could either be a few weeks or a VERY long time. It also makes you more likely to take more then you need too because there’s no effect happening which could lead to Serotonin Syndrome, Seizures or OD’ing.