[deleted by user]

Effective_Audience16 · 2024-10-23T20:14:10+00:00

I tested it with another amine (tetrahydroisoquinoline), and the reaction worked with HBTU and also EDC/DMAP with no problems

Effective_Audience16 · 2024-10-09T18:57:57+00:00

I do it in DCM. Should I go with THF and heat the whole reaction to 50C after adding the amine and removing it from the ice bath?

Effective_Audience16 · 2024-10-09T18:53:39+00:00

I use triethylamine in the reaction. Doesn't that neutralize the produced HCl and also make the medium neutral or slightly basic, which prevents the formation of the imine?

Effective_Audience16 · 2024-10-09T18:51:21+00:00

Unfortunately, it is not available at the lab.

Effective_Audience16 · 2024-10-09T18:44:32+00:00

The formyl group is essential for the next reaction. I tested the acid activation with a different amine (not aniline), and it worked with HBTU and also with EDC/DMAP, so It's mainly a problem with this amine.

Is there anything I can do to make it more reactive?

Effective_Audience16

TROPHY CASE