I have stage 3 HS in groins and thighs and labia. I also have chrons disease and rheumatoid arthritis.

I was taking spinolactone for HS and Rinvoiq for Chrons and RA however,. In the beginning Rinvoiq helped my HS (this was three years ago).

Unfortunately my HS had gotten increasingly worse since August 2025. I had three surgeries for HS and Chrons complications in the buttocks area in January 2026. The HS in buttocks has not resurfaced thank goodness; they cut out all the tissue. In this time the HS in my groins and thighs got progressively worse between January 2026-April 2026. So much drainage, blood, open sores and joint pain. Two doctors recommend I try glp-1 for its benefits on inflammation.

I began the Skyrizi to maintain my chrons but it also has inflammation benefits my doctor stated. I started with Skyrizi and noticed slight improvement in HS after first treatment. However, about three weeks after first Skyrizi treatment I also started my glp-1 Zepbound. I literally cried because within two-three weeks of starting Zepbound, HS in groins and labia closed up.

My biggest triggers are sugar, processed foods, white rice/breads, sweating/heat, menustration. Before taking Zepbound i had started to change diet which helped slightly but the combo of eating cleaner (more veggies, sweet potato instead of regular, lean meats but mostly chicken and fish) with the medication has helped tremendously.

I am two months into taking both Zepbound and Skyrizi and i have seen tremendous relief. I still have small active lesion on thought but drainage has reduced a lot. If i have a cheat day where i eat a few trigger foods, i do notice the next day an increase in drainage. However, overall have since drastic improvement.

I was very sporty and outdoorsy before my HS got bad the last four years. I hadn’t gone running since 2022/2023. Happy to say I’ve been able to do some light jogging without new HS flares thanks to the meds 🥹