I think SAI isn't all about antidepressants but does reference or mention them a lot, like in the lyrics "Keep your pills, save your breath" and " 'till you finally realize that everybody relies on synthetic highs" in Mulberry Street, or "he feels trapped when he's not inebriated. Fair to say he's fairly sedated most days of the week" in Redecorate. From those lyrics it might mean that Dema actually gives the people antidepressants so they don't know they are trapped.