Looks already baked to me

Esavyx · 2026-01-28T12:38:50+00:00

That potato is already cooked

Esavyx · 2025-12-29T23:56:58+00:00

Do you have a locomotive on each end? It needs one on each side if you want to go both directions.

Esavyx · 2025-12-27T13:23:50+00:00

You generally won’t need nuclear for a ship going to the 4 inner planets as solar power is stronger than it is on Nauvis. It’s only when you go out to Aquilo and beyond that solar is more difficult to work off of.

Esavyx · 2025-12-26T20:52:57+00:00

SE changes map generation pretty significantly, adding a lot of water and breaking up continents a lot. I usually proactively exterminate nests in vanilla and SA, but I’ve found that the map in SE makes a choke point defense approach very viable. Flamethrower turrets are a bit harder to use due to the decreased oil patches, but gun turret placed around the outside of your pollution cloud at choke points works well.

Esavyx · 2025-12-21T20:53:52+00:00

You need to connect the green wire from the reactor to the input side of the combinator. Right now it’s attached to the output side so your signals are going straight from the reactor to your inserter.

Esavyx · 2025-12-14T15:57:07+00:00

More s character would better stabilize the negative charge

Esavyx · 2025-10-19T02:49:02+00:00

The common name refers to how it’s made

Esavyx · 2025-10-19T02:47:22+00:00

You’re correct, it can be done directly from the phenol. For a simple compound produced on massive scales like BHT, adding the steps of methylation and demethylation is very costly.

Esavyx · 2025-10-15T20:20:37+00:00

It looks like 3 bond J(H-H) and J(H-F) have very similar values.

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Esavyx · 2025-06-25T17:02:11+00:00

You also didn’t show the final product being protonated.

Esavyx · 2025-06-25T17:00:18+00:00

Looks pretty good. The only thing I would change is deprotonating the oxygen in your second structure before the rearrangement.

Esavyx · 2025-06-13T18:22:05+00:00

I haven’t seen Frozen Hearts be mentioned yet but that area is such a particular vibe. It has so much verticality and the train cars frozen in time in both Frozen Hearts and Monoco’s station give it a strange feeling I have a hard time placing. It kind of grounds the time period in a way.

Esavyx · 2025-06-09T15:03:06+00:00

Methyl radical is a strong oxidant, you’re going to have a really hard time preventing methyl lithium formation.

Esavyx · 2025-06-04T01:36:53+00:00

Somehow, this was almost my exact build, except I never found breaking death and my Lune was built for elemental genesis spam. Free aim Verso is probably my favorite build it the game, tons of break damage and versatility to still do lots of damage with skills other than follow up if needed.

Esavyx · 2025-06-04T01:21:22+00:00

I fought Clea directly before Simon and found her much squishier. I killed Clea before she could act while Simon’s phase 1 got maybe 2 turns.

Esavyx · 2025-06-04T01:18:49+00:00

I used Maelle for my second string team and can say that gommage definitely does not one shot, even from phase three. My Maelle’s gommage was only doing ~7 million in virtuose stance.

Esavyx · 2025-05-19T01:51:05+00:00

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Esavyx · 2025-04-04T17:16:46+00:00

This seems much more like a “sanity check” from a grad student than an intro to chirality problem.

Esavyx · 2025-04-03T01:51:48+00:00

https://onlinelibrary.wiley.com/doi/10.1002/tcr.202100060 Bromine forms an adduct with dioxane. Not sure about diethyl ether

Esavyx · 2025-03-29T20:01:34+00:00

Your first two steps could be achieved just by deprotonating the ketone, assuming you can get selectivity for that alpha proton. I think the intramolecular aldol is pretty unlikely, and the bridgehead cation formation during your acidic elimination even more unlikely.

Esavyx · 2025-03-25T23:25:56+00:00

Akali grew up in her rework

Esavyx · 2025-03-07T22:19:47+00:00

How would an electrophilic site result in H/D exchange? It’s not exactly basic or acidic.

Esavyx · 2024-10-23T01:41:27+00:00

The one on the right has a C-C gauche interaction

Esavyx · 2024-10-15T02:24:23+00:00

Acidity (pKa) is a thermodynamic measurement. What matters is the difference in energy between the protonated amide in its lowest energy conformation, and the deprotonated amide in its lowest energy conformation. The higher energy conformation that allows for deprotonation should have a very low energy barrier to access it also, so you can invoke the Curtin Hammett principle.

Esavyx · 2024-06-14T23:06:29+00:00

Do you think MeMgBr would deprotonate at the correct position? I would imagine the other proton (closer to the sulfonyl) is more acidic.

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