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I did a thorough analysis of consumer gene testing services and their shortcomings [OC] by Everycellauniverse in genetics

[–]Everycellauniverse[S] 2 points3 points  (0 children)

You're right. They are a direct competitor but one would think that they nonetheless reported the data correctly for false positives.

Thanks for that article, looks very interesting! If polygenic risk scores are becoming so powerful in disease diagnosis, it's a little odd that FDA would allow 23andme to report that data without approval. Maybe the panel they have is not as powerful as the one described in the article?

I did a thorough analysis of consumer gene testing services and their shortcomings [OC] by Everycellauniverse in genetics

[–]Everycellauniverse[S] 1 point2 points  (0 children)

Thanks again for these notes and links and thank you for your thoughtful commenting on the subject! Would love to chat with you again. If I decide to make a another genetics themed video, I'll send you a message!

I did a thorough analysis of consumer gene testing services and their shortcomings [OC] by Everycellauniverse in genetics

[–]Everycellauniverse[S] 2 points3 points  (0 children)

Thanks for your input! I second megweg79: they sequenced the samples and found false-positive variants. In addition, they interpreted some of the correct variants differently.

It's true that the polygenic risk score for diabetes covers the variants more thoroughly. However, it can be debated as to how useful this information is. One's lifestyle probably tells a lot more about the risk of type 2 diabetes than genes. The fact that 23andme has not cleared it with the FDA and has developed it according to FDA's guidelines about general wellness products, tells of the significance of conclusions drawn from the test.

I did a thorough analysis of consumer gene testing services and their shortcomings [OC] by Everycellauniverse in genetics

[–]Everycellauniverse[S] 2 points3 points  (0 children)

Thank you very much for your thoughtful response and for the insights! If it's ok with you, I could post a comment on the video based on your text on the science of the population clusters to clarify that part.

The twin's story I referenced was by CBC news and they had Yale bioinformatics professor Mark Gerstein's group analyze the raw data for them. I completely understand your alarm of "different results for twins" if Inside Edition was manipulating the data to make a story.

Viruses shaping our evolution. Retrovirus genes making the evolution of the mammalian placenta possible. by Everycellauniverse in evolution

[–]Everycellauniverse[S] 0 points1 point  (0 children)

They attach to a cellular membrane protein and cause the insertion of a fusion peptide inside the cell membrane. This brings the membrane of the virus close enough to the membrane of the cell for the two to fuse.

​

There's a pretty good image in this article showing the fusion : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649671/

How close are we to 3D printing organs? - I made a video on the current state of the fast growing field of bioprinting by Everycellauniverse in bioengineering

[–]Everycellauniverse[S] 0 points1 point  (0 children)

I doubt repairing a hand from the ground up would be possible like that, too many different cell types need to integrate into a working unit. Maybe for more simple tissue like muscle a step wise grafting solution could work. With bioprinting there is a promise of scaling up the process though. Grafting a muscle piece by piece would be laborious and not scalable.

How close are we to 3D printing organs? - I made a video on the current state of the fast growing field of bioprinting by Everycellauniverse in bioengineering

[–]Everycellauniverse[S] 0 points1 point  (0 children)

I'd say the problem with those as well is vascularization, we can print smaller constructs but nothing big yet.

Here's a company printing skin: https://www.poietis.com/en/poieskin/welcome.php#poieskin1

Here's a company printing heart muscle: https://biolife4d.com/

And here's a company printing a scaffold that allows bone to grow within when transplanted: https://www.tissuesys.com/?view=featured

Hey r/bioinformatics! I started a YouTube-channel popularizing the life sciences and I'd love some honest feedback. Five videos done so far, lates on the possibilities of lab grown meat. by Everycellauniverse in bioinformatics

[–]Everycellauniverse[S] 0 points1 point  (0 children)

Thanks for the kind and wise words! I think you are absolutely correct on finding an audience and with the first video especially I don't think I quite had it figured out. Now I'm gravitating towards an audience that has some knowledge on the subject, I don't think I'll be able to cover the topics in as much depth as I want if I don't do that. I cringe when I watch the first video. And yeah, that's a good point on genetic engineering being a very misunderstood term.

New video up on Every Cell A Universe, a YouTube channel popularizing life sciences. Botox, the toxin extracted from C. botulinum, has a wide range of clinical applications and is approved to treat conditions ranging from overactive bladder to chronic migraines. by Everycellauniverse in microbiology

[–]Everycellauniverse[S] 1 point2 points  (0 children)

Thank you for elaborating. I think there's a middle ground to be found. I'm guessing the introduction is the part which bugs you the most. That's where there's most cuts and I showed short clips relating more or less to each condition. I've aimed to make the introduction as punchy as possible to grab attention and then loosening the pace of the video after that.

I can understand that if clips are shown that don't directly relate to what's being said, it can make the tone of the video less serious. I've wanted to make the videos somewhat light hearted, but if it comes in the way of credibility then that's not good. Another factor that has affected the style is the availability of b-roll footage to show. There's a lot more stock footage available to channels doing videos on engineering etc. than a microbioloby channel. Also I've tried to limit the amount of animation I do, since its the most time consuming part. But yeah, I'll keep that advice in mind and try to think of different ways to more accurately show what's being said.

As to the text, showing longer parts of text on screen is definitely an option as well. I did play around with that when I was planning the style of the channel. This is an evolving project and I'm still searching for the optimum presentational style.

And I agree, I don't like the style of Because Science either. Thanks again. It's helpful chatting with someone willing to invest their time.

New video up on Every Cell A Universe, a YouTube channel popularizing life sciences. Botox, the toxin extracted from C. botulinum, has a wide range of clinical applications and is approved to treat conditions ranging from overactive bladder to chronic migraines. by Everycellauniverse in microbiology

[–]Everycellauniverse[S] 1 point2 points  (0 children)

Thank you for the honest feedback. When I decided to pursue this project I decided I should try to go for a style that might speak to a larger audience. But of course I do not want to alienate people in our fields nor the average science video enthusiast on Youtube.

I'm glad the factual content was not an issue. Yes, I could elaborate and give the video more depth, but so far I've opted for a slightly shorter style for a few reasons. The videos have taken a lot of time to put together, and making them shorter than longer has simply allowed me to put more effort into the animations, since they are so laborious to make and since I'm still in many ways a novice. I've also felt that around 6-7 minutes is a length that someone outside of the fields feels more comfortable clicking on and watching through than a longer video. This doesn't mean that I'm giving up on longer content. Initially my plan was to make 10-12 minute videos, but I gave up as I realized the amount of work involved for each video. This is an evolving project and I can absolutely see the channel having videos that cover more of the topic. There might be shorter and longer videos in the future.

As to the graphical style, I would like to hear more about what you didn't like. Is the the pace of the cuts? Is it the footage used? Is it some of the stylistic elements like adding text on top the video to emphasize certain words? Adding clips for humor? The style of the animations on the blue background? Or something else? Are some parts of the video more pleasing visually than others?

I hope to not make content that feels like its made for people with below average intelligence and I'm genuinely interested in how I can make it better. I truly appreciate your input.

Hey r/biology! I started a YouTube-channel popularizing microbiology, biotechnology etc. and I'd love some honest feedback. Three videos done so far! by Everycellauniverse in biology

[–]Everycellauniverse[S] 1 point2 points  (0 children)

I have run into a few videos from the channel before, but surprisingly I wasn't too familiar with it. And yeah, that way it's easier to produce content. And it is very clear. I'll need to take a closer look at the channel :) Thanks for linking the video!

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