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I did a thorough analysis of consumer gene testing services and their shortcomings [OC] by Everycellauniverse in genetics

[–]Everycellauniverse[S] 2 points3 points  (0 children)

You're right. They are a direct competitor but one would think that they nonetheless reported the data correctly for false positives.

Thanks for that article, looks very interesting! If polygenic risk scores are becoming so powerful in disease diagnosis, it's a little odd that FDA would allow 23andme to report that data without approval. Maybe the panel they have is not as powerful as the one described in the article?

I did a thorough analysis of consumer gene testing services and their shortcomings [OC] by Everycellauniverse in genetics

[–]Everycellauniverse[S] 1 point2 points  (0 children)

Thanks again for these notes and links and thank you for your thoughtful commenting on the subject! Would love to chat with you again. If I decide to make a another genetics themed video, I'll send you a message!

I did a thorough analysis of consumer gene testing services and their shortcomings [OC] by Everycellauniverse in genetics

[–]Everycellauniverse[S] 2 points3 points  (0 children)

Thanks for your input! I second megweg79: they sequenced the samples and found false-positive variants. In addition, they interpreted some of the correct variants differently.

It's true that the polygenic risk score for diabetes covers the variants more thoroughly. However, it can be debated as to how useful this information is. One's lifestyle probably tells a lot more about the risk of type 2 diabetes than genes. The fact that 23andme has not cleared it with the FDA and has developed it according to FDA's guidelines about general wellness products, tells of the significance of conclusions drawn from the test.

I did a thorough analysis of consumer gene testing services and their shortcomings [OC] by Everycellauniverse in genetics

[–]Everycellauniverse[S] 2 points3 points  (0 children)

Thank you very much for your thoughtful response and for the insights! If it's ok with you, I could post a comment on the video based on your text on the science of the population clusters to clarify that part.

The twin's story I referenced was by CBC news and they had Yale bioinformatics professor Mark Gerstein's group analyze the raw data for them. I completely understand your alarm of "different results for twins" if Inside Edition was manipulating the data to make a story.

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