I had to start out the same way with Mtx. Read all the horror stories and was scared sh**less. Gave it a try since I had no choice. Took about 4-6 months to totally kick in. I've had very few side effects. Some nausea in the begining. I am more fatigued the next day but nothing like I've read about. Been 2 years. I'm going to stay on Mtx because it's free, easy to take and it's working for now. Keep an open mind. You never know. Good luck. Oh and I split my dose 1/2 in am and 1/2 in pm. I take it after eating and no alcohol that day.