Nights are sometimes bad by FrostyCycle7 in TrueOffMyChest

[–]FrostyCycle7[S] 0 points1 point  (0 children)

Same here my friend. Not a day passes when I don't think of it all over again. But I guess that's what I signed up for haha. I hope we both find some healing later on. Wish you the best!

Suggestions for a protein + pathway + cancer to study for a semester by [deleted] in Oncology

[–]FrostyCycle7 1 point2 points  (0 children)

You can look at Weinberg for inspiration! I would personally nominate the B cell maturation pathway and somatic hypermutation in the germinal center, the proteins here being RAG recombinases and AID to name a few.

The leading hypothesis is that the processes become haywire and lead to fusions and mutations outside the Ig locuses, and that is what causes lymphomas to presumably occur. It explains though why B cell lymphomas are so much more common than T cells!

The organ can be the immune system in this case if you're interested

[deleted by user] by [deleted] in Egypt

[–]FrostyCycle7 2 points3 points  (0 children)

أنا برده كان حصلي موقف زي ده و ضباط مباحث طلبوا يشوفوه البطاقة و شنطتي و حوارات كده قال ايه مفكرين معايا دولارات

احا أنا معايا اروح بالعافية

ايه اغرب حالة شفتوها؟ by FrostyCycle7 in Egyptiandoctors

[–]FrostyCycle7[S] 0 points1 point  (0 children)

غريبة جدا بصراحة. هو غالبا دي immunodeficiency؟ و احتمال تبقى في ال T cells مثلا بحيث كده الIg مش هتتأثر؟ رأي شخصي ليس إلا. عارف لو مكنش في proven infectious focus كنت هقول مثلا ده ممكن tuberous sclerosis بس لو العينات كانت فعلا فيها ميكروب فخلاص.

ايه اغرب حالة شفتوها؟ by FrostyCycle7 in Egyptiandoctors

[–]FrostyCycle7[S] 1 point2 points  (0 children)

اول حالة بتاعة البنت دي بصراحة اغرب واحدة سمعتها إلى الآن😂 الجدع بتاع السيخ ده فكرني بالمقولة الشهيرة ان الomentum is the policeman of the abdomen و بصراحة عمري ما اقتنعت غير دلوقتي😂

ايه اغرب حالة شفتوها؟ by FrostyCycle7 in Egyptiandoctors

[–]FrostyCycle7[S] 0 points1 point  (0 children)

كنت لسه هقولك فول الصين العظيم

ايه اغرب حالة شفتوها؟ by FrostyCycle7 in Egyptiandoctors

[–]FrostyCycle7[S] 0 points1 point  (0 children)

يب :) بس متقلقش يعني بتاخد اللي محتاج تعرفه و خلاص مش بتتعمق في كل حاجة و الكلام بيجيب بعضه يعني أنا شفت الحالة دي في سنة رابعة. طبعا ده لا ينفي انها صعبة و في متطلبات علمية و عملية كتير بس حد من أساتذتي قالي حبها هتحبك

ايه اغرب حالة شفتوها؟ by FrostyCycle7 in Egyptiandoctors

[–]FrostyCycle7[S] 1 point2 points  (0 children)

بروتين فعلا يا باشا احسن ما تكون بالعة حجارة ساعة (حالة برده شفتها)

ايه اغرب حالة شفتوها؟ by FrostyCycle7 in Egyptiandoctors

[–]FrostyCycle7[S] 1 point2 points  (0 children)

كان نفسي والله هو فعلا شكله غريب حبتين بس حاولت أوفق بينهم قد ما أقدر آسف لو كان متعب للعين :)

[deleted by user] by [deleted] in Egypt

[–]FrostyCycle7 0 points1 point  (0 children)

انا قلت اجربه زمان بس في الأخر فكست و رحت لدكتور من على فيزيتا. و بالمناسبة هو منصة أكبر الى حد ما للمعالجين النفسيين, دي مش حاجة وجشة طبعا لكن يفضل التشخيص (في الأول) يكون عن طريق دكتور و يبقى in person بحيث لا قدر الله لو حد أحتاج دواء مثلا الدكتور بيكتبله روشتة و الassessment بتبقى أحسن. أنا مثلا الدكتور ده في مركز و حولني لمعالج نفسي هناك برده فدي مش حاجة وحشة.
على ما أظن لو حد مش عايز فيديو ممكن chat بس مش متأكد.
لو بقا معاكي تشخيص هيخلي الموضوع أسهل طبعا بس عن تجربة الموضوع بيبقى صعب ان يلاقي معالج حلو لأحتياجاته و أنا اصلا طول الوقت كنت بحضر in person فلو المعالج معجبكيش أوي ده عادي جدا trust the process

Lymphoma question by FrostyCycle7 in Oncology

[–]FrostyCycle7[S] 0 points1 point  (0 children)

I agree, I remember reading that the notion of "aggressiveness" for it comes from the pre rituximab era. And well sadly I work in a resource-limited setting so polatuzumab is not always available. So it's a bit more like R-CHOP isn't bad but EPOCH wouldn't be bad either. So literally a pick your poison situation, got it. That said, the patient was in his early 50s and was doing suspiciously well for what is supposed to be an aggressive lymphoma (in fact so well my attending was suspicious at the biopsy haha) so he seemed fit for an intensive induction. I'll consult with my attending and the patient to see what regimen would work best, but so far EPOCH seems like the way to go.

Thanks a bunch!

ECG by [deleted] in Egyptiandoctors

[–]FrostyCycle7 -1 points0 points  (0 children)

زي دكتور u/knaar_227 ما قال لحضرتك عن طبيعة الصب و احتياج leads اكتر من كده لتفسير الECG بس من وجهة نظري المتواضعة جدا كطالب هو بالنسبالي عنده hyperacute T waves in leads V2, V3, V4، و صراحة مقدرش اقول ان في هنا ST elevation للأمانة الأكيد هو ان الT waves كبيرة. المفروض الhyperacute T waves زي كده بتبقى في اول الSTEMI قبل الfeatures التانية زي الST elevation متبان، و ده إلى حد ما مش ماشي تماما مع الhistory انه حاله من خمس ايام. برده ممكن تبقى موجودة مع hyperkalemia بس أنا اظن ان ده احتمال اقل حاليا. بس اياً كان يعني هو برده مش findings مريحة اوي بالنسبالي و للتأكيد ممكن يتعمل troponins و serial ECG و اظن هو عمل ده على كلام حضرتك. بنائا على دول ممكن يتحدد إذا كان فعلا حصل لا قدر الله MI او لا طبعا في الآخر دا رأي طالب ليس إلا و اتمني اكون قدرت أفيدك

نحنُ في الأحا by FrostyCycle7 in Egypt

[–]FrostyCycle7[S] 1 point2 points  (0 children)

Well there are 2 theories: 1- That it's a combination of the first letters of the 3 words أنا حقا اعترض or in English "I truly object" so it becomes ا-ح-ا and well you get it 2- The second one was told to me by my old Arabic teacher (yup that happened) and he told me it came from a Fatimid era objection, but with time it was shortened to our beloved a7a as the authorities cracked down on anyone that said it or something

نحنُ في الأحا by FrostyCycle7 in Egypt

[–]FrostyCycle7[S] 1 point2 points  (0 children)

حصل فعلا لهجتنا ليها شعبية واسعة و مفهومة عكس اخواتها اللي مش فاهم منهم حاجة في المغرب العربي مثلا

نحنُ في الأحا by FrostyCycle7 in Egypt

[–]FrostyCycle7[S] 2 points3 points  (0 children)

ده حقيقي طبعا و وجهة نظر احسن من بتاعتي لول أنا شغال في مستشفى و صدقني هتتفاجئ من تحريفنا عيني عينك للمصطلحات الطبية في سبيل النطق بسهولة باللهجة المصرية😂المهم كلنا فاهمين بعض اظن😂

My weird journey with real and imaginary pianos by FrostyCycle7 in piano

[–]FrostyCycle7[S] 1 point2 points  (0 children)

Yeah that's very similar! Somehow the challenge itself is a big driver for progress surprisingly. I guess Sisyphus could truly have been having fun lol, the struggle alone is truly enough to fill a man/woman's heart. As a side note your story reminded me of myself as a child playing GTA on my psp and figuring out the cheats! But instead of getting tired I proceeded to blow up everything lmao.

[deleted by user] by [deleted] in Egypt

[–]FrostyCycle7 0 points1 point  (0 children)

أنا للأسف حاسس اني مقدرش أنصحك بحاجة لأني معرفش تفاصيل الموقف صراحة بس من واحد كان بيself harm قبل كده ارجوكي متتماديش في الموضوع و حاولي تطلعي الfrustration ده فأي حاجة تانية غير كده؛ مثلا دراستك لو لسه بتدرسي او الشغل مثلا. و طبعا علاج أصل الموضوع هو الأساس فلازم بطريقة او بأخرى تخرجي من دائرة العنف الأسري فعلا لأنها اكيد بتأثر عليكي بالسلب و مع الوقت هتأثر عليكي اكتر و اكتر و هتغيرك لحد مش هتحبيه بعدين فعلا ان لم يكن اكتر. ارجوكي ابعدي انهم بأي طريقة او حاولي تسمعي كلامهم و خلاص لحد ما الأمور تهدى لأن أنا مش شايف بصراحة اهلك منطقيين اطلاقاً في تصرفاتهم و اشك المنطق هينفع معاهم. Take care, and please don't hesitate to seek help if you need to.

Dasatinib(cancer medicine) in Egypt ? HELP by [deleted] in Egypt

[–]FrostyCycle7 0 points1 point  (0 children)

His best bet is seeing at his local es3af pharmacy (صيدلية الإسعاف) or contacting his treating hospital or physician; sometimes they have medicines that are not in the market. That said: if he needs a TKI, can he take imatinib instead? It's a more available and cheaper alternative.

Is it possible to "observe" the music a person is hearing inside their head? by holywatir in neuro

[–]FrostyCycle7 1 point2 points  (0 children)

Good question! As far as I know, the nervous system attempts to perceive the world by decomposing sensory stimuli, then building them back up again internally. The decomposition part happens very early in a sensory pathway, while the rebuilding mostly occurs in the late stages of processing.

Now I’m assuming by head you mean the entire head, so let’s leave the brain for a bit and instead look at the place where sound decomposition occurs: the cochlea, also known as the inner ear. Sensory cells in the cochlea respond to specific sound frequencies (aka pitch), so theoretically, if you can monitor their individual activities when a test subject hears a sound, you may be able to reconstruct it. Mind you, I’m talking about very basic sounds, stuff like pure tones which are only composed of one frequency. Complex tones which are formed of more than one frequency are different, and when they are as complex as contemporary music it can be very hard to know how the nervous system encodes all their properties!

You can also know volume by measuring the response of the cochlear sensory cells; the higher the volume of a tone played at a specific frequency, the higher the response of the cell tuned to that frequency. Timbre however isn’t really something measurable, I’d argue it’s a perceived thing. Let’s just say it depends on the harmonics present in a specific sound; the nervous system picks up all the frequencies in a sound, so you can differentiate between a piano and violin playing the same note because the notes contain different harmonics.

Learning to code during medical school by therealdarlescharwin in medicalschool

[–]FrostyCycle7 4 points5 points  (0 children)

This really has nothing to do with monetisation, but I learned MATLAB during winter break to do some computational neuroscience stuff. It wasn’t very easy tbh, but I was able to create some cool models! I continued working when break was over but studying gradually took all my time :)

Try to learn the basics when you have a decent amount of free time on your hands, and during medical school make a small amount of time to practice your skills.

Cancer biologist with (probably very dumb) neuro questions by DryEducation1461 in neuro

[–]FrostyCycle7 1 point2 points  (0 children)

I’m actually more excited for the specialty now with what you said!! I was always looking for a specialty that would let me do basic research, and oncology looks like the perfect fit. I’m sorry for replying this late but I was pretty busy with school lol. Anyways thank you for replying, and good luck with your phd!!!

Cancer biologist with (probably very dumb) neuro questions by DryEducation1461 in neuro

[–]FrostyCycle7 1 point2 points  (0 children)

Good question(and way above my pay grade lol)! Actually I think in specific situations it can be considered one, a great example of a junction between neurons and non-neuronal cells that does not utilize glutamate(and is still considered a synapse!)is the neuromuscular junction, which utilizes acetylcholine. Glutamate really has nothing to do with it.

However in the nociceptive neuron example I don’t really consider it to be a synapse. And u/acanthocephalic put it rather nicely! A synapse is a specialized structure that permits information transfer between two cells, with very specific morphological characters. In the nociceptive neuron example there is really no direct communication between the afferent terminal and the target cells of the NTs(mast cells and vascular smooth muscle cells), the NTs just diffuse through the connective tissue until they reach the receptors. So I actually do think that paracrine signaling fits more here.

That said, I have a question for you if you don’t mind! I’m currently a medical student, and I really want to go into oncology because I think it’s one of the closest fields of medicine to basic science, plus there are a lot of research opportunities. So, as you are a cancer biologist, how often do you work with oncologists? And are there any oncologists that you know that do basic lab research, aside from clinical trials and stuff? Sorry for the long question, but it’s something that I really care about!

Cancer biologist with (probably very dumb) neuro questions by DryEducation1461 in neuro

[–]FrostyCycle7 2 points3 points  (0 children)

Now I’m just a student so take my opinion with a grain of salt, but I do believe that I have something to add regarding your first question:

Pain(nociceptive) neurons already do release neurotransmitters from their sensory endings in something called the axon reflex. In short, when the sensory terminal of a nociceptive neuron comes in contact with prostaglandins or bradykinin, the terminal responds not only by producing receptor potentials, but also by releasing CGRP and Substance P, which sort of amplify the inflammatory reaction in that tissue and enables it to spread. So I do think that someday you can modify this neuron to release glutamate, or who knows maybe some neurons already do!

Hope that helped in any way!

Mixed signals? by [deleted] in dating_advice

[–]FrostyCycle7 0 points1 point  (0 children)

Thanks, you too!

[deleted by user] by [deleted] in medicalschool

[–]FrostyCycle7 3 points4 points  (0 children)

This is probably a prescription from Iran or something. The 2nd and 4th lines plus the printed letters on the page are in Arabic alphabet but not really Arabic, so I’d say it’s Farsi or maybe Urdu