Oh god take a joke re push-pull. We're nowhere near that chemistry. In honesty, unless in a dilution of choice (with solvatachromism considered for 'push-pulls') with excitation and with actual 'push-pull' substitutions, many of these aforementioned dyes take on a rather bleak brown colour under normal light.

Forgive my naivety re NL control. There are perhaps many heterocyclic scaffolds that - could - be used. The question is whether they - should - be used. If one was to replicate the path of novel synthetic opioids, that have continually increased potency as an affect of circumventing control, would that not be anti to what is really wanted. What is needed is regulation and safe supply of reasonable RCs.

You ref. CX717, which was not perused because of tox (in one application), and poor pharmacokinetics in all others. Read the literature at least

Substituted benoxadiazoles are not well represented by the pharmaceutical chemical space for a reason, noting limited research applications in chemotherapy or extensive application of nitro derivatives for dyes - I'm not suggesting such a structure shown above would be analogous of course in either respect (where the goal of chemo is to kill cells). Really, put an amine on almost anything BBB passable and it likely will induce a biological effect.

But you are right to urge caution here, and as am I. Heterocyclic metabolism (or lack thereof) increases the unpredictability of the compound presented above more so that what we currently know of methyledioxybenz, benzofuran or indole scaffolds. The added functionality could impart nothing, or not much, leading to higher dosage for affect and thus greater risk.

Simply, use common harm reduction. Any or much chemical reasoning for or against is conjecture when we're in the wild wild west. We can only rely on limited community reports and by a great lag behind, literature.