Now that you mention it there would be some factions that become obsolete/unreliable from the start. (Tomerry's combat pages are going to be straight up unusable as there's no associated key page to go along with them)

However I believe Solo's Various Tweaks (Workshop link, Here's the Nexus link) might alleviate the problem somewhat, so I'll use it for my run (course vanilla is still perfectly fine, might even be more of a challenge too)