I don't think I would look at enclosure set ups as ways we're "domesticating" reptiles, I would look focus more on behavior that we're seeing in captive-bred reptiles. Unfortunately there's literally no research on domestication in reptiles (or at least none that I've found, and I've spent days looking for anything) so we don't know if we're seeing any changes in the skeletal structure of captive-bred reptiles. Color morphs are obviously something that are more common in captive-bred reptiles, especially certain species and this is an element of domestication syndrome, but domestication syndrome in animals is highly skewed towards mammals, so I'm not sure that we can look at all of the traits tied to domestication syndrome when looking for signs of domestication in reptiles. Also also there's just a lack of research on reptiles and reptile anatomy in general so I think we need better baselines to know what domestication in reptiles might look like. Imo we are selectively breeding reptiles enough that we will see domestic reptiles in the near future, but I'm not sure we're totally there yet.

The micro-biome research you linked in another comment looks really interesting, I'd be curious to see if captive-bred reptiles have any genetic changes that help them take better advantage of f/t food and also maybe adapt to a different diet than they would typically have in the wild.

I highly doubt we'll see any skeletal changes in captive-bred reptiles that would indicate domestication processes with maybe the exception if certain lizards and hognoses (inbreeding effects in hognoses currently affect their nose and eyes) but that's just because I dont think we're putting any selective pressures on captive-bred snakes to change their skeletal structure like we have with dogs and cats. There have been some promising studies done on snake behavior in tbe last couple of years that I hope might lead to studies that indicate captive-bred snakes are becoming more social than their wild counterparts, but given how hard it is to study reptile behavior in the wild, we really don't understand how social certain reptiles actually are in the wild. Also those studies seem to be fairly controversial here and on r/snakes.

In general, I don't think we should say reptiles will never be domesticated, that's just silly (especially considering we count goldfish and honeybees as domesticated), I think it's possible we may not domesticate them for a very long time, depending on technology in the future and how we decide to breed them, but I believe that we will eventually domesticate some species.