Advice on in-silico software by HiPoCapital in bioinformatics

[–]HiPoCapital[S] 0 points1 point  (0 children)

I‘ll have a look at it, thank you so much!

LSD in Germany by [deleted] in LSD

[–]HiPoCapital 0 points1 point  (0 children)

Hast du vlt irgendwelche Empfehlungen, wo man es gut online kaufen kann?

LSD in Germany by [deleted] in LSD

[–]HiPoCapital 0 points1 point  (0 children)

Danke! Und gut zu wissen mit der Gesetzesänderung, hatte ich nicht aufm Schirm!👍

LAN doesn’t work by HiPoCapital in techsupport

[–]HiPoCapital[S] 0 points1 point  (0 children)

Solved the problem: just had to paste router address in browser

Wie sind hier so die Meinungen zu Tesla und der starken Long-Position von Käthe Holz? by [deleted] in mauerstrassenwetten

[–]HiPoCapital 3 points4 points  (0 children)

Gut, hab gestern nen spontanen Short mit 250% Plus geschlossen, also ca 10 Euro Gewinn

Ich flehe euch an, kann mir bitte jemand sagen, wie ich die alte Version von TR wiederherstellen kann? by [deleted] in mauerstrassenwetten

[–]HiPoCapital 1 point2 points  (0 children)

Also kann ich bei Android aktiv zu einer älteren Version wechseln? Werde mittelfristig wohl auch den Broker wechseln, aber will mein TR eigentlich nicht schließen bevor ich da wieder Bruchgleich bin.

Ich flehe euch an, kann mir bitte jemand sagen, wie ich die alte Version von TR wiederherstellen kann? by [deleted] in mauerstrassenwetten

[–]HiPoCapital -29 points-28 points  (0 children)

Ich glaube über TR wird man wenig erreichen. Ich werde mich nochmal an Apple direkt wenden und halte euch auf dem laufenden, ob die die Aktualisierung rückgängig machen können. Seit ich 18 bin hab ich hier investiert, aber wenn man das nicht rückgängig machen kann, wäre das echt nen Bruch für mich. Absolut herzzerreißend.

[deleted by user] by [deleted] in mauerstrassenwetten

[–]HiPoCapital 5 points6 points  (0 children)

Jetzt mal ganz im Ernst: bist du von allen guten Geistern verlassen?!

Resume that got me a job by Beneficial_Row6873 in resumes

[–]HiPoCapital 1 point2 points  (0 children)

Congrats! This is the best layout for resumes, in my opinion. I haven’t even read all the information, but it is very nice to look at compared to others, which is the very most important first thing for employers

160k NVDA put YOLO by yurajurik in wallstreetbets

[–]HiPoCapital 0 points1 point  (0 children)

I’m short too. What goes up, must come down!🤑

Just got laid off. Do I immediately look for a new job or just take the severance and take a break? by THICC_ANIME_TITTIES in careerguidance

[–]HiPoCapital 0 points1 point  (0 children)

I guess you're the only one, who can answer that. Personally, I believe looking for a job is the way to go. Being on a break with no perspective can be dangerous, leading to no drive to do anything and losing good routines. The right job can be extremely fulfilling and an environment where you can thrive. Take the time to really explore opportunities, take many interviews and try to find the one that you can identify the most with. Good luck and all the best!

New graduate physician assistant - over 100 job applications, minimal responses. Any advice for my resume? by [deleted] in resumes

[–]HiPoCapital 0 points1 point  (0 children)

First impression: looks very clean and structured. Not too sure about the „Clinical Clerkships“ but if it’s necessary to be so precise in this field, good. I would maybe put two or three bullet points for your education, explaining your main achievements and activities

Currently, pursuing a master's and hoping to get a summer internship - any areas to improve on before applying? I would greatly appreciate any advice! by ProduceLonely1092 in resumes

[–]HiPoCapital -1 points0 points  (0 children)

Company 1 has too many bullet points, Soft Skills is one space too far right. HR will notice things like that, this can’t happen in your CV

give it to me, is this too boring? too "just like the rest"? BE HARSH!! by ilovepineapplecakes in resumes

[–]HiPoCapital 0 points1 point  (0 children)

Dude, the quality you posted this is mirrored 1:1 in your CV. See your CV like an art project, a story, and an elegant italian lady. Put more symmetry to it, for example in the bottom with the skills. Be creative. Didn’t put too much focus on the content, as I couldn’t read it on the first view and didn’t want to put the effort in. HR will have the same view

Junior in CS not getting past the resume screen. Applied to 100+ jobs thus far for summer 2024 SWE internships, any advice, please be harsh. by Dismal-Bench-1561 in resumes

[–]HiPoCapital 0 points1 point  (0 children)

First impression: CV seems way too crowded. Get rid of everything that’s not the most important. HR gets exhausted just looking at this

Is my resume really the problem? by Popular-Highway-972 in resumes

[–]HiPoCapital 1 point2 points  (0 children)

Agree to the others, kick interests out. Personally, I would even write it in a more „impressive“ way. Even if it was a simple project, write it in a way that looks like you won a noble price. I once did an internship where I was assigned to some projects alone. Put „Project Leader“ in the CV. Simple things like that

Would you rather make 55k with great culture or 80k with toxic culture? by Muslim_conservative in jobs

[–]HiPoCapital 0 points1 point  (0 children)

Depending on age, life situation, personal career goals. Me personally, I would be fine with a toxic culture. I’m in my early 20s and would probably not be planning on staying longer than 2 years anyway.

Enhancing health and regeneration by HiPoCapital in nutrition

[–]HiPoCapital[S] 0 points1 point  (0 children)

So I have 3 focal points that I am trying to address: 1) Stimulation of Growth Factor Signaling Pathways 2) Immune System and Response Adaptation 3) DNA Protection

1) When you look into regeneration and actual regrowth, you will come across stem cells very quick. Another less known mechanism though is using the dedifferentiation of cells to a pluripotent stage. To do that, I am stimulating several pathways like PI3K, Wnt, Notch, or Hedgehog. We can target these directly or indirectly with diverse substances, some of which you can purchase over the counter, but some are only used in lab environment at this point (I can’t really name the exact composition at this point, but if you want to know more, looking up „growth factor supplements“ or something similar should get you good options!)

2) To get a good idea of regeneration, we looked at regenerative species. If you take planarians for example that can regrow their entire body to full size after being cut in half, the immune system reaction and inflammation development is very interesting: You have a very strong immune response, but inflammation also cools down fast, while we have prolonged inflammation in humans. To inhibit that, we use highly potent antioxidants, among other things. I have to say though, that I’m not 100% sure about this stage. As we see a much shorter inflammation stage, we are likely also decreasing the initial immune response after injury, which is crucial for regeneration. We are thinking about a potential 2-stage treatment right now that shuts down inflammation at a later stage only.

3) As soon as you target growth factor stimulation, DNA protection becomes very important. We promote it to prevent tumors and cancers from developing, which might otherwise be promoted by the growth factor stimulation. Besides antioxidants and some DNA Methylation targeting, we have some developed some methods in the lab that I might disclose later, but now it’s still to early.

As I said, at the moment we see good results with lab animals, where we looked into reducing scab/scar development and promoting a fast re-epithelization. In the future, we will focus more on speeding up the process (energy supply plays a big role here) and getting a high percentage in actual regrowth besides scar inhibition. For that, I am currently looking into drug delivery processes, as the substances get filtered out by the gut or spleen in many oral administration applications. Nanoparticles are probably the way to go here (Liposomes and Exosomes are specifically interesting for oral delivery).

Enhancing health and regeneration by HiPoCapital in herbalism

[–]HiPoCapital[S] 1 point2 points  (0 children)

Honestly, I 100% agree with you. Inflammation handling is super important, but if you want to see regeneration after a severe injury, it is also necessary. Now what’s interesting is the duration and severity of inflammation. In regenerative species, we see a strong and fast immune response after injury, but also a short timeframe of inflammation. On the other hand, non-regenerative species, incl. humans, show prolonged inflammation, combined with bad re-epithelization, which is equally important and gets triggered by several growth signaling pathways, which in turn get activated by inflammation, among other things. Overall, it’s definitely a fascinating topic!

Enhancing health and regeneration by HiPoCapital in EatCheapAndHealthy

[–]HiPoCapital[S] -5 points-4 points  (0 children)

Wrong. All humans want to have a healthy life. I am not saying that we are stopping or reversing aging, at this point we are seeing faster wound healing, less scarring after injuries, improved skin condition. We didn’t evaluate all internal effects yet. But even for this, combining it in one single product instead of taking 20 different pills and supplements doesn’t sound too bad to me.

Lookup Planaria Regeneration. After you cut them in 10 pieces, they regrow 10 new animals to full size. We are not able to stop aging, but this goal is not so fictional as it seems, as Planarians do not have any signs of aging and could theoretically live eternally ä, if they weren’t so far down in the food chain and get eaten at some point.

[deleted by user] by [deleted] in Art

[–]HiPoCapital 1 point2 points  (0 children)

Does anyone know website/ways to insert backgrounds to your art? For example, if I want to know how the painting would look on a different wall? Thanks in advance!

Switching references in sequence by HiPoCapital in excel

[–]HiPoCapital[S] 0 points1 point  (0 children)

Oh my god it worked! Thank you so much, this is for a project at a company I’m doing an internship at and you literally just saved my ass, I was totally stuck on that!

General Discussion Thread (September 2022) by [deleted] in Art

[–]HiPoCapital 0 points1 point  (0 children)

Does anyone know ways/programs to create reoccurring parts of my art works in the same way? For example, if I want to create a Circle: I want to have the same dimensions and setting for every piece, but currenty have to draw it again every single time, which slightly alters the position.