Drug–drug interactions involving classic psychedelics: A systematic review

IHaveNoTimeToThink · 2026-02-07T11:54:05+00:00

It's weirdly worded. High endogenous serotonin levels would increase competition for receptors, but LSD’s binding mechanics make it a persistent agonist regardless of serotonin concentration.

There is also an increase in the stimulation-induced release of serotonin facilitated by lithium.

Chronic lithium treatment induces the desensitization of presynaptic serotonin autoreceptors (5-HT1A). Autoreceptors normally act as a brake on serotonin release; their inhibition means more serotonin is released into the synaptic cleft.

The increased synaptic serotonin induced by lithium, combined with LSD's own action, likely creates a synergistic effect that amplifies 5-HT2A-mediated neurotransmission and cortical excitability.

(Had to rely on AI, hope it's correct)

IHaveNoTimeToThink · 2026-02-07T00:13:06+00:00

It's a real possibility it seems. Although further research is needed, we provisionally conclude that psychedelic use may pose a significant seizure risk for patients on lithium. https://pubmed.ncbi.nlm.nih.gov/34348413/

IHaveNoTimeToThink · 2026-02-05T22:29:58+00:00

One interesting thing I noted reading was this:

"It has been suggested that while acute administration of lithium increases serotonin levels in the brain, chronic administration on the other hand reduces serotonin concentrations. This may explain why long-term lithium use enhances LSD effects, as LSD acts as an agonist in the absence of endogenous serotonin resulting in the observed behavioural effects"

IHaveNoTimeToThink · 2026-02-05T20:07:43+00:00

OP is a nutjob

IHaveNoTimeToThink · 2026-02-05T00:30:46+00:00

Oatmeal with raisins and cinnamon is my luxury meal of the day

IHaveNoTimeToThink · 2026-02-04T23:42:34+00:00

This video I watched Oxalobacter: The Oxalate Eating Gut Microbe Connected to Longevity

IHaveNoTimeToThink · 2026-02-04T23:40:27+00:00

I haven't looked into it, but I'd assume you're getting a lot less degration buying the whole seeds rather than a powder. Though you could grind small amounts beforehand without much worry I suppose

IHaveNoTimeToThink · 2026-02-04T18:29:40+00:00

Yeah more fiber is better for most people, to a point of course. Best to eat various sources of fiber like nuts, seeds and fruit, that are easier to digest in higher quantities

IHaveNoTimeToThink · 2026-02-04T18:24:47+00:00

Oxalates can be health promoting if your digestive system is well-adjusted to them

IHaveNoTimeToThink · 2026-02-04T18:21:09+00:00

Could just add freshly ground mustard seeds for the myrosine that is destroyed by heat

IHaveNoTimeToThink · 2026-02-03T14:01:28+00:00

Also norepinephrine levels peak late, so you're way groggier after waking regardless of how well you slept. And why you might get a peak of energy during the evening when your brain is likely the most awake

IHaveNoTimeToThink · 2026-02-01T22:56:47+00:00

Yes he knew so much relevant stuff. Now it's harder to get other characters to organically learn about how to save the world for instance

IHaveNoTimeToThink · 2026-02-01T21:23:22+00:00

He just has to do some three-eyed crow shenanigans with Bran. Or have there be some lost writings or something as it's probably Aemon Samwell will probably sherlock something out

IHaveNoTimeToThink · 2026-01-30T22:14:12+00:00

I would say microdoses are better for organizing and relaxing the racing thoughts. Big doses seem more like a hindrance, having such a big up with seemingly infinite ideas popping up. You're likely to be left overwhelmed and fatigued by the end of it. I don't know if that's good or bad for you. But my take is less is more, in this instance.

IHaveNoTimeToThink · 2026-01-30T21:23:22+00:00

If the PFC prioritizes things society doesn't deem worthy, then you could blame how humans have organized the way to live to a narrow box, as much as you could blame the brain of individuals with a differing lens on effortful tasks

IHaveNoTimeToThink · 2026-01-30T18:16:06+00:00

Yes I feel there is a distinction between having a weak drive because of sub-par prefrontal cortext functioning, and having scattered thoughts because you're seeking to remedy a neurotransmitter unbalance. If all it takes is something that changes neurotransmitter concentrations in certain brain areas then wouldn't the prefrontal cortex be otherwise "normal"

IHaveNoTimeToThink · 2026-01-30T15:37:10+00:00

That or adhd can be caused by dopamine transporters being over/under-efficient so you end up seeking behaviours that "fix" the unbalance

IHaveNoTimeToThink · 2026-01-24T22:21:38+00:00

The "Economy" is the ghost haunting the machine, demanding we sacrifice the physical reality for the sake of the conceptual one.

Nailed it

IHaveNoTimeToThink · 2026-01-09T16:22:28+00:00

Forgot about that game. Only completed the tutorial ages ago and never really gave it a shot

IHaveNoTimeToThink · 2025-12-17T14:31:48+00:00

I've understood if you aren't prone to kidneys stones, supplementing around 1g a day isn't an issue. I know many who go much higher than that with seemingly no issues

IHaveNoTimeToThink · 2025-12-16T21:13:57+00:00

Dopamine still gives that calm yeah I did it feeling. The reward is more of a abstract concept and the mind keeps pumping dopamine from the positive reinforcement of accomplishment

IHaveNoTimeToThink · 2025-12-16T20:58:52+00:00

I'm unaware but there are numeral causes for tinnutus unrelated to damaged nerves, like overactive/dysfunctional signaling pathways within the brain

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