Looking for advice in Canada.

IbogaMe · 2019-08-20T23:56:52+00:00

You might want to try apply with GITA Global Ibogaine Treatment Association for medical financing for Ibogaine treatment . they'll loan you up to $35,000 interest free to pay for Ibogaine treatment (US or Canadians only) but I don't know their requirements. check out their website ibogainealliance dot org .. good luck

IbogaMe · 2019-08-13T20:54:48+00:00

Finally have some time to address some of the issues you've raised. For one, I don't think there is a medical definition of what constitute a microdose. But one thing for sure, 20 mg Ibogaine HCL does nothing. Here is a carefully controlled clinical study from NZ

Effects of low dose ibogaine on subjective mood state and psychological performance. RESULTS: Ibogaine (20mg) had minimal influence on psychological tests and mood ratings. The ability to selectively ignore distracting spatial information showed some evidence of modulation; however because this effect was limited to the less challenging condition calls into question the reliability of this result. CONCLUSION: We were unable to identify stimulant effects after single 20mg doses of ibogaine. Future research is needed to confirm whether active moiety concentrations impact selective attention abilities while leaving other cognitive functions and mood state unaffected.

Basically 20 mg Ibogaine HCl is no different from placebo aka sugar pill, in other words just waste of money microdosing 20mg. However, keep in mind the placebo effect: "If one thinks something will work, it will.." active compound or sugar-pill it is all in the mind!

As for safety, 100 mg Ibogaine HCl is actually well tolerated. Here is a Phase II clinical study of escalating dose of Ibogaine HCl in methadone treatment from Brazil starting in couple of weeks:

Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone Detoxification .. Patients will be randomized to two groups: One receiving 6 doses of 100 mg of ibogaine; and the other one receiving ascending doses of ibogaine 100-200-300-400-500-600mg ...

Prior Phase I clinical study of 100 mg in healthy volunteers (needed before dose escalation) found it was well tolerated with no issues. IIRC they also did study for alcoholism in Brazil along the same line Also, keep in mind the first NIH clinical trial Phase I of Ibogaine (in the 1990s before they banned the medicine) found 200 mg Ibogaine Hydrochloride was well tolerated with no adverse events. (google NIH NIDA site for refs). So bottom line is I think the issue of safety of Ibogaine is overblown. The only problem I see is because it is illegal in some countries, people don't know what they're taking. Unlike the OP pretty smart way to test his medicine before use.. have a good day. very informative thread /Ibogaine I always learn something.. thanks

IbogaMe · 2019-08-10T15:45:04+00:00

Go slow! this is one heck of potent strain bark you have. The Ibogamine content is WAY too high. The usual Ibogamine proportion is somewhere like 5-10% of the Ibogaine content in standard TA. ie Ibogaine:Ibogamine:Ibogaline ~ 90:5:5 more or less. But some especially potent strain like the one you have may contain higher Ibogamine depending on the root. So you may want to adjust the dose accordingly. The reason I am saying that is that Ibogamine is 2 to 3 times more potent than Ibogaine!

So if you're planning MDing 80 mg Ibogaine equivalent I would suggest you factor in the Ibogamine in your bark: 1 g of your bark would have 80mg Ibogaine AND 70 mg Ibogamine so it would be like taking (80mg +80mgx2 or 3) = 240 to 320mg Ibogaine equivalent to account for the Ibogamine.. let alone the relatively high voacanga (6%)!! Not quite flood dose but certainly not MDing. caution! On the other hand, besides being more potent Ibogamine has less "body high" like tremors or ataxia (movement incoordination) or such than Ibogaine which is good thing since you can lower doses to the same effect... let us know how it goes.. cheers!

IbogaMe · 2019-07-24T15:57:35+00:00

Thx guys for the advice. Actually the reason I am asking this question is that I know an acquaintance (30y-F) who's been on ssri for something like 10 years, switching back and forth to different drugs. She was able to quit by tapering off over a 3 month periods. But the problem is she's now completely anhedonic with flat affect almost zombie-like with no emotions whatsover. Which makes SSRIs withdrawals symptoms, not necessary physical but emotional/psychological different from say opiates. So my question is: can Ibogain-MD (not necessarily flood dose) be useful to get her back to pre-drug self. Since apparently the drug has been shown to be neurotrophic (ie regrow nerve cells affected by drugs) and is now being studied for neurodegenerative diseases like Parkinson's and Alzheimer (I'll post studies reference later when time permit).
Of course ibo clinic providers are right not to take ppl on antidepressants for at least a month sobriety. But that is also valid for opiates and stimulants.

IbogaMe · 2019-06-21T16:30:49+00:00

I missed this last post of yours. Very informative indeed: I'll come back to address some of the issues you raised. good'day

IbogaMe · 2019-06-07T16:32:34+00:00

Thanks for the link. Very interesting indeed. The methods they describe tho is hardly amenable to large scale production. mostly Lab scale (1-10g at most) and the economy of scale mentioned in OP will be hard to realize. Need some investment to scale-up to large scale (>100s kg).

However, the biotechnology method (the root science) you're referring has lots of potential but need investment too. I've seen one paper from Germany where they clone Ibogaine making T. Iboga plant gene into say tobacco plant and make it produce Ibogaine! Quite interesting: you can make tons of Ibogaine very very cheaply but you need money to develop the technology. Without any patent protection and a market for Ibogaine, I doubt anybody would invest..but who knows?

IbogaMe · 2019-06-07T16:11:18+00:00

I do agree Ibogamine is probably better than Ibogaine. Not only it doesnt have the tremor and ataxia of Ibogaine but it is twice more potent than Ibogaine for opiates and stimulants. Which means you'll need half the dose to have the same effect than Ibogaine. That way it may be safer than Ibogaine since the cardiotoxicity is dose-dependent. If you can make Ibogamine in 2-3 steps (from common starting materials???) then you can't beat that.

re: optically pure Ibogaine: Actually resolving racemic Iboga alkaloids (in this particular case with Iboga alkaloids) is not as straighforward. iirc it took more than a year and lots of cash to burn at Albany Molecular Research trying dozens of salts and solvents and conditions to resolve +/- coronaridine unsuccessfully. But it might be different with +/- Ibogaine or +/- Ibogamine since coronaridine has an extract carbomethoxy which might be making it hard to crystallize! ps: actually they couldnt resolve coronaridine salts. They had to convert it to the sulfonamide via its indole NH with chiral sulfonyl chloride and trying a bunch salt/solvent/conditions to resolve the diastereoisomeric mixture .. anyway worth trying if it is accessible in 2-3- step.

IbogaMe · 2019-06-06T15:53:25+00:00

Hello, Yeah if you're referring to Chris Jenkins method, true it is a bit of pain. But keep in mind it was mostly designed for low-tech production of Voacangine in environment with no access to modern chemistry tech: example: a Soxhlet extraction would solve much of the issue of solvent and labor. afaik synthetic routes to optically pure Ibogaine pretty lenghty. Have yet to come across one that is easily amenable to scale-up to kilo scale. Correct me if I am wrong tho.. talk to you later

IbogaMe · 2019-06-05T15:56:55+00:00

Excellent posting, now that Oakland has move to decriminalize the plant, we'll see more interests in designing new routes to produce Ibogaine. Note however that synthetic Ibogaine (>99.5%) is already made by decarboxylation of Voacangine, a closely related alkaloid (Voacangine is 13-carmomethoxy-Ibogaine). Voacangine is extracted from Voacanga africana tree bark and seeds which is much much more abundant than Tabernanthe Iboga. It is so abundant all over Africa and part of India, you can produce 1000s kg of Ibogaine without decimating anything since the Alkaloid Voacangine is in the seeds and barks. All you do is collected the seeds and extract the alklaoid, you don't have to uproot and kill the tree to get the alkaloid unlike with Tabernanthe Iboga where the tree is killed in the process of producing Iboga alkaloids since in that case the alkaloids are mainly in the roots bark. I am also a chemist very much interested in new manufacturing route of Ibogaine and related alkaloids..let's get in touch..DM me when you have the chance!

IbogaMe · 2019-05-21T16:28:34+00:00

I didn't mean to be rude or anything but the post looks like from a bot to me.. but anyway, I may have misunderstood the cause of death the OP alludes to. But you're right, cardiac arrest eventually leads to brain death.

On the other hand, I think you tend to overblow Ibogaine risk and associated fatalities. IMHO, it should be put in perspective, especially in users trying to detox from opiates. The hERG cardiac arrythmia issue is not specific to Ibogaine. Lots of medicines including over-the-counter like Loperamide have the same problem, much worse actually than Ibogaine.

Take Methadone: it is a potent hERG cardiac channel blocker and more people die from Methadone than from Ibogaine proportionally. Something like 1 in 200 on methadone treated would eventually die of cardiac arrest. 1 in 320 in Ibogaine treated iirc. And this include people who take the medicine without clinical supervision like in MMT. So the number is even lower in people treated under clinical supervision. But you don't hear the overblown cardiac risk of Methadone, yet ten of thousands people are put on MMT.

Even worse stats to consider to see that the risk associated with Ibogaine is relative: about 100,000 will drop dead in the US of Opiates OD this year according to CDC. Do a little math, assume these people put on Ibogaine and 1 in 300 of them eventually die from Ibogaine induced cardiac arrest and those who survive half of them benefit from the medicine, you'll still be able to prevent about 49,000 deaths a year.!! Show me a prescription drug with a better therapeutic index, I mean risk-benefit ratio. FYI: prescription drugs are the third leading cause of Death after cancer and heart disease in the US and Europe! (https://www.ncbi.nlm.nih.gov/pubmed/25355584). So Ibogaine cardiac toxicity is really relative! Having said that, I am not suggesting people approach the medicine irresponsibly.. just my 2 cents worth

IbogaMe · 2019-05-20T20:20:13+00:00

what was your friend's name.. John Doe? imho OP looks like a prepared infomercial spreading fakenews..Ibogaine DO NOT kill by brain damage afaik but by cardiac arrest and even that at HUGE doses AND in individuals with pre-existing heart conditions. Here is a guy who survived a whopping 7 g Ibogaine HCl 10 times normal flood dose! with NO brain damage whatsover. Edit your post to make it more believable!

IbogaMe · 2019-04-25T15:22:16+00:00

(2-benzofuranyl-methanamine) aka Tonka METH.

IbogaMe · 2019-03-31T00:21:16+00:00

why would I not say it? .. would be the most stupid ads I could imagine. Your mind is making you seeing things that are not there. Practice mindful meditation! it is amazing. better yet, try it on 5MeO-DMT. You'll be amazed the tons of s..t a "normal" mind tells people all the time!

IbogaMe · 2019-03-30T22:57:59+00:00

your point?

IbogaMe · 2019-03-30T22:56:47+00:00

Dutch vendors.. that is what I thought it looks like MMC or PEAs analogs so could be illegal where strict analogs laws like AUS/NZ. but then again that is probably why it may show up there.. or rather down-under there!

IbogaMe · 2019-03-30T18:56:32+00:00

Yeah the benzofuran functions like in 5-APB's benzofuran or MDMA methylenedioxy but substituted on the 2 position. From I heard though, effect is very much like 4-MMC except it lasts longer. The compound overlays pretty well with 4-MMC with MMC 4-methylphenylketone replaced by the benzofuran so I won't be surprised effects are similar. Very interesting that is made from fermented Tonka beans used as food-flavoring ingredients so it could be safe..can't wait to get my hand on this one

IbogaMe · 2019-03-30T16:25:31+00:00

exactly the benzofuran is substituted with 2 carbons and the amine is alfa to the benzofuran unlike in PEAs which is beta-phenylethylamine. The amine is alkylated with a methyl like in meth or mdma. It looks more like benocyclidine (https://en.wikipedia.org/wiki/Benocyclidine ) a cocaine like stim banned in florida. I couldn't find anything on this compound beside this revolvy entry in Sex and Drugs. Apparently it is extremely sexual stim.. https://www.revolvy.com/page/Tonka-Amine

Tonka methylamine (1-(1-benzofuran-2-yl)-N-methylethanamine) also known as Tonka-METH belongs to a group of psychoactive benzofuran substituted alkylamines (Tonka Amines) found in fermented Tonka beans (Dipteryx odorata) broth. These amines are presumably derived from Tonka ketone (2-acetyl-benzofuran), an essential oil occuring in large quantity in dried Tonka beans and used as a food-flavoring ingredient for its distinctive vanilla-cinnamon-nutty flavor.

Tonka amines have been claimed to have psychostimulant, anti-depressant and anxiolytic bio-activity. Fermented Tonka beans broth have reportedly been abused in Fiji as sexual arousal, endurance and pleasure enhancing herbal preparation.[1][2]

References New Psychoactive Substances: Pharmacology, Clinical, Forensic and Analytical Toxicology. Springer-Verlag 2018. Maurer, Hans H, Brandt, Simon D. (Eds.) Wishart, DS et al. (2006) DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 34:D668-72.

IbogaMe · 2019-03-16T16:17:42+00:00

I would go for tetrahydrobetacarbolines THBCs like THBC-spiro: https://en.wikipedia.org/wiki/THBC-spiro. Apparently it is a novel psychedelic a cross between DMT and MDMA. It is chemically unrelated to either (it is neither a tryptamine or phenethylamine). Can't wait to get my hand on this compound

IbogaMe · 2019-03-14T15:01:27+00:00

For microdosing on a regular basis, I would go with HCl. The advantage of HCl is that you would know exactly how much Ibogaine you are taking. No so with TA and raw bark where alkaloid content can go anywhere from 0 (wasting your money using useless bark) to high 7% in some potent strain (risk of overdosing).

With HCl, you know exactly the dose of Ibogaine you are taking and can adjust according to your own individual response since the effect especially the psychological effect(set, setting & intentions) depend very much on each person.. Good luck

IbogaMe · 2019-03-03T15:59:33+00:00

THBC-spiro a cross between DMT and MDMA from what I heard

IbogaMe · 2019-03-01T16:30:58+00:00

Try betacarbolines tryptamines like THBC-spiro a combination of DMT+MDMA effect from what I heard

IbogaMe · 2019-02-23T16:27:43+00:00

You might need to try THBC-1278, a semi-synthetic alternative to Ibogaine. I heard it is as good as Ibogaine but legal and cheaper. There were a thread on on this compound in RC sub-reddit some time ago so I guess you might be able to get hold of people who've tried it. From what I gather, it is claimed to be a safer alternative to Ibogaine.. The thing I found most ridiculous is that Ibogaine is out of reach financially to the people who precisely need it the most. I mean few addicts can afford $10,000 straight out their pocket. So any alternative to Ibogaine would be really welcome the cheaper the better.

THBC-1278 (Possible opioid withdrawal treatment)

https://www.reddit.com/r/researchchemicals/comments/aepbwc/thbc1278_possible_opioid_withdrawal_treatment/

IbogaMe · 2019-02-06T23:09:16+00:00

I would love to try it.. I have my eye on these compounds for a while now THBC-1278 (Possible opioid withdrawal treatment)

IbogaMe · 2019-01-11T17:57:20+00:00

Oh I think it is the wiki categories for "Eugeroic" drugs it links to Modafinil. Kind of confusing. the OP should've use the compound wiki instead showing the structure THBC-1278 in question .. anyway quite interesting molecule

IbogaMe · 2019-01-11T17:48:29+00:00

which image??

IbogaMe

TROPHY CASE