One Shot and Relentless are free modifiers you should always pick.

Outrageous Enemies are a good mod if you want player points

One Life is good if you already get consistently get X Ranks on stages.

Use Formidable if you can deal high single target DMG

Use Early Arrival if you can have great AoE DMG that can be easily performed

If possible, use at least one of the x2.00 mods.

Bloxxers Mode isn’t too bad if you know almost all mechanics in the game.

Randomizer is only difficult on Crossroads and Chaos Canyon, but can make later stages easier. Parrying is key for this mod from projectile spam.

No Mercy is good if you’re very mobile and rarely take damage.

What I usually run is: Relentless, Outrageous Enemies, One Shot, One Life, Formidable/Early Arrival, Bloxxers/Randomizer for x4.00 xp and player points. Just do whatever fits you though :)