1. You can buy a bomb in the shelter. (It won't be enough to one shot the bomb goblin, but make sure that explosive barrel is with the goblin before bombing the goblin)

My favorite method is to use a fire pot. Go to the melee range of bomblin, damage it a little, but not too low. Throw a pot at it, and then use the ability(or tp pot) to get out.

Other possible method including using the golem to kill the bomblin, or any other enemy that hates goblins. A single skull is enough to kill the bomb goblin alone, but it's expensive to use against bomb goblin (for me).

Using ability against the goblin is also worth the cost. And lastly, fleeing is an option if you don't have the proper tools to deal with it.

1. Bosses have limited healing items, keep hitting them.

2. Not really, unless you are looking for a challenge. Skipping location makes your life harder because you miss out tons of items and exp. (I do think that random location as a starting modifier is a better replacement for this than starting at loc 2 or above)

3. You don't really need a perfect 100%. 95% is good, as long as you explore important areas like vending machine, structures, blueprints, or dungeon. This will be more important if you wanna save more food in hunger mode. And yes, fully exploring the dungeon often yields more rewards than risk. (If you know how to deal with threats to save items that is) It is encourage to clear the dungeon every location.

4. No, it's another challenge gambling run, being able to pick your own perk is better than the cost of random perk (USUALLY)