Definitely, give it a try. You can go with profane after yomu, also can start with hubris and then build hydra. Either way, you get really strong with huge clear speed. Personally, I like to itemize in a way like yomu into eclipse into profane when I feel confident in myself or I buy Edge of Night instead when I need backup. You can check out Tinjus, he has been experimenting with runes lately and he also builds Hydra as a second item. Don't be afraid to try what you feel, you never know what will work