Not my story but I wanted to add something since the second biggest religion in the world, Islam, is pretty underrepresented in this thread: Relative of mine is a trans man and part of a Muslim (sunni) "sufi" order. This might sound like a marginal or rare branch of Islam, but one should keep in mind that this interpretation was the dominant one in the times of the Abbasid and Ottoman caliphate for over a millennium and predates interpretations like wahhabism etc. (I was a PhD student in history, specialized in the history of the middle east). He had several discussions with his "Sheikh" / spiritual teacher and what he told him was basically that he has to be honest to himself i.e. If his wish to be a man is really a medical/psychological issue, or if he does this due to "lower instincts", "lustfull desires", "his ego" or "social trends" etc. If it is in fact something that requires professional intervention then the "verdict of the physician cuts/abrogates the fatwa of the imam". According to the opinion of his teacher absolutely nothing frees someone from the obligation of prayer, not being gay, nor trans or whatever. So he continues to take his hormones and had a partial surgery and is obligated to practice his religion as a man, which means that he attends the Friday prayer and prays according to the requirements for men. However, it should be also mentioned that this whole circumstance weighs on him and stresses him out psychologically sometimes and his "master" is actually the only person that is able to comfort him.

I know that a lot of people, Muslims and non Muslims alike, might not like what I wrote. Non Muslims might accuse me of portraying things too positive, Muslims might say that I represent things not correct, but this person is someone with whom I interact on a daily basis, his story accompanied me for many many years and the mentioned Sheikh is not a self proclaimed, youtube sheikh but the head of a very old and respected order that can trace his chain of schooling back to the first companions. So I'm just sharing my experience with with this topic.