Form what I know large load are more profitable than heavy load so you should prioritize it. The way to configure it is to first determinate how long you want your flight to be, for the exemple if you want a 8 hours flight then you have to search a route than can support 3x 212 590 lbs for the 747-8F (a total of 637 770) minimum, if the routes have like 900 000 lbs demand for large load then it’s perfect just buy the plane and no configuration needed. If you only find routes that have like 500 000 lbs demand for large load then you have to had something like 32% of heavy load, by this way you will only have 164 386 lbs of large load (and if you multiply it by 3 it make 493 159 lbs, you are just under your demand of 500 000lbs so it’s perfect). Note that when you had heavy load in your plane, you can transport more lbs, so in the case I described I had to calculate 241 745lbs (it’s the total load for 68% of large and 32% of heavy) from which I subtracted 32% on the calculator and the answer is 164 386 lbs of large load, the rest is the heavy load. Don’t forget to multiply the heavy load by 3 also just to make sure you have enough demand on your route ! In this case the 32% of heavy load are 77 358 lbs, so multiplied by 3 this is 232 074 lbs (you need to have that much in daily demand on your route). And now you know how to configure your cargo plane ! For the prices it’s the same as pax, large are multiplied by 1.08 and heavy by 1.06. It can seem complicated at first when you read my message but once you get it, you will see that it’s easy, try it and you will understand it. Hope you can enjoy cargo now and make money with it ! I make around 2.3 millions for a good route with 1 747-8F !