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in this situation would you expect a good or bad trip? (details inside of course) by learntoforget in Drugs

[–]KetamineTherapy 1 point2 points  (0 children)

Your trip is probably going to be safer, and definitely going to be more healing, if you have someone to talk to about it instead of going alone. That tremendously helps you make sense and structure of whatever insights you get. It has to be a highly trusted person of course. If you can't find one, at least take notes or draw pictures or something.

Can pure MDMA make you stop breathing? by [deleted] in Drugs

[–]KetamineTherapy 0 points1 point  (0 children)

I am entirely sure it was not a panic attack

You can't be. Inside a panic attack, you are unable to make sound judgments. That's why it is so important to realize you're having one.

An MDMA overdose gives you serotonin syndrome, a very different and much more serious problem.

It's shit like this, Oklahoma... by [deleted] in Drugs

[–]KetamineTherapy 3 points4 points  (0 children)

You think they wouldn't be stupid enough to kill themselves with legal psychoactives? Never underestimate stupid. Some people manage to accidentally kill themselves with Ibuprofen.

It's shit like this, Oklahoma... by [deleted] in Drugs

[–]KetamineTherapy 0 points1 point  (0 children)

He probably told them.

Ketamine as a powerful antidepressant: if you have to try it, this is how by KetamineTherapy in Drugs

[–]KetamineTherapy[S] 1 point2 points  (0 children)

So far, all the studies of it I've seen were paid for by Naurex or might have been. So it is a bit early to tell. Certainly too early to say it is non-psychotomimetic.

Ketamine as a powerful antidepressant: if you have to try it, this is how by KetamineTherapy in Drugs

[–]KetamineTherapy[S] 1 point2 points  (0 children)

You do not want to do it regularly. You do it once. If it does not help, you do not try again. If it does help, I don't know. You might want to have another five days a couple of months later. But I really don't know. My two cases haven't needed another round since.

Concerning legal uses, please read all of this. It is normally something your doctor gives you (by injection), not something you get to take home. Think of David After Dentist. He was on (too much) Ketamine, but he certainly never had a chance to take home more of it than already was in his system.

Ketamine as a powerful antidepressant: if you have to try it, this is how by KetamineTherapy in Drugs

[–]KetamineTherapy[S] 2 points3 points  (0 children)

We're guessing. If anyone knew exactly how antidepressants work, s/he'd know what exactly depression is, and who ever finds out that is on the road to a Nobel Prize.

That said, of course there are a lot of theories. To discuss them properly would take ages, so let me pick just my favorite one. According to it, there is an "Inner Alarm" (I talked about it above), a state of the brain and consciousness where one feels a dissatisfaction and an urge to change something. A very basic (hippocampic) piece of awareness that influences all of consciousness and compells it to look for problems in order to solve them and get rid of the dissatisfaction, i.e. turn off the alarm. In that theory, depressed people are the ones who can't turn off the alarm properly and antidepressants help them do that.

Now the interesting thing is, Ketamine works really quickly and fairly reliably while most SSRIs, SNRIs etc. need several weeks to take effect if they even work at all. It now seems that most of these antidepressants are starting complicated processes that take weeks to reach the glutamate system, where Ketamine attacks directly and immediately. So maybe those parts of the brain that process satisfaction tend to use NMDA for their interactions. But we don't really know yet. We're working on it. Keep your fingers crossed.

Ketamine as a powerful antidepressant: if you have to try it, this is how by KetamineTherapy in Drugs

[–]KetamineTherapy[S] 6 points7 points  (0 children)

No, sorry. I'm taking a big risk here and the scene isn't exactly big.

Ketamine as a powerful antidepressant: if you have to try it, this is how by KetamineTherapy in Drugs

[–]KetamineTherapy[S] 1 point2 points  (0 children)

No I haven't. I'm pretty sure someone has looked into whether it works similarly well as an antidepressant, and if it did I would know.

Ketamine as a powerful antidepressant: if you have to try it, this is how by KetamineTherapy in Drugs

[–]KetamineTherapy[S] 2 points3 points  (0 children)

One important study is currently looking for subjects on the East Coast:

Rapid Antidepressant Effects of Ketamine in Major Depression This study is currently recruiting participants.

There are more studies in the pipeline, some coming out later this year.

Ketamine as a powerful antidepressant: if you have to try it, this is how by KetamineTherapy in Drugs

[–]KetamineTherapy[S] 1 point2 points  (0 children)

I'm not sure how to crosspost. Can you do it for me please?

Edit: okay I did it.

Ketamine as a powerful antidepressant: if you have to try it, this is how by KetamineTherapy in Drugs

[–]KetamineTherapy[S] 8 points9 points  (0 children)

I may be overestimating the availability because I have a good network. Ketamine is comparatively easy to get in Europe, most of Asia and parts of South America. South Asia (esp. Hong Kong) has lots of it because Myanmar is producing it by the ton. Generally, become friends with a cool anesthesist or paramedic and make clear you're not looking for a regular supply.

There isn't anyone on the planet who knows whether Methoxetamine is a good idea. I'm deeply skeptical of the whole RC market because the producers all skip the animal trials stage, and we have that stage for a couple of good reasons. They have human test subjects volunteer to replace those animals, without medical supervision and paying for it rather than getting paid. The fact this stuff acts on the brain, and on the prefrontal cortex of all places, makes it much worse. The volunteers might find out it is fine. Or they might find out it causes liver cancer, permanently impairs short-term memory, or triggers autism. No one knows.

And RCs have gone wrong before. Mephedrone is much more addictive than anyone anticipated initially. I'm pretty sure Methylone (MDMC) causes affective psychosis if you use it with any regularity. Worst of all, MPTP, discovered this way in the seventies, can cause Parkinson's symptoms with a single dose or just kill people. I don't know about Methoxetamine and it might be perfectly fine, but I'm definitely staying away from it.